Publicação
Control of satellite cell function in muscle regeneration and its disruption in ageing
| dc.contributor.author | Sousa-Victor, Pedro | |
| dc.contributor.author | García-Prat, Laura | |
| dc.contributor.author | Muñoz-Cánoves, Pura | |
| dc.date.accessioned | 2022-01-28T16:01:57Z | |
| dc.date.available | 2022-01-28T16:01:57Z | |
| dc.date.issued | 2021 | |
| dc.description | © Springer Nature Limited 2021 | pt_PT |
| dc.description.abstract | Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically and usually by asymmetric cell division to replace myofibres damaged by daily activity and maintain the stem cell pool. However, satellite cells can also be robustly activated upon tissue injury, after which they undergo symmetric divisions to generate new stem cells and numerous proliferating myoblasts that later differentiate to muscle cells (myocytes) to rebuild the muscle fibre, thereby supporting skeletal muscle regeneration. Recent discoveries show that satellite cells have a great degree of population heterogeneity, and that their cell fate choices during the regeneration process are dictated by both intrinsic and extrinsic mechanisms. Extrinsic cues come largely from communication with the numerous distinct stromal cell types in their niche, creating a dynamically interactive microenvironment. This Review discusses the role and regulation of satellite cells in skeletal muscle homeostasis and regeneration. In particular, we highlight the cell-intrinsic control of quiescence versus activation, the importance of satellite cell–niche communication, and deregulation of these mechanisms associated with ageing. The increasing understanding of how satellite cells are regulated will help to advance muscle regeneration and rejuvenation therapies. | pt_PT |
| dc.description.sponsorship | ork in the authors’ laboratory was supported in part by the Spanish MINECO (RTI2018-096068), ERC-AdG-741966, LaCaixa-HEALTH-HR17-00040, MDA, UPGRADE-H2020-825825, MWRF, FundacióLaMaratóTV3, AFM and DPP-Spain (P.M.-C). P.M.-C’s laboratories at Pompeu Fabra University and the Spanish National Center for Cardiovascular Research are recipients of grants from the María de Maeztu Units of Excellence programme to Pompeu Fabra University (MDM-2014-0370) and the Severo Ochoa Centers of Excellence programme to the Spanish National Center for Cardiovascular Research (SEV-2015-0505) for P.M.C. Work in the P.S.-V. laboratory was supported by the Fundação para a Ciência e Tecnologia Project (PTDC/MED-OUT/8010/2020), an EMBO installation grant (IG4448) and the ‘la Caixa’ Foundation for a junior leader fellowship (LCF/BQ/PI19/11690006) to P.S.-V. L.G.-P. was supported by an EMBO long-term fellowship (ALTF 420-2017), a Benjamin Pearl fellowship, and a CIHR fellowship (201910MFE-430959-284655). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Nat Rev Mol Cell Biol. 2021 Oct 18 | pt_PT |
| dc.identifier.doi | 10.1038/s41580-021-00421-2 | pt_PT |
| dc.identifier.eissn | 1471-0080 | |
| dc.identifier.issn | 1471-0072 | |
| dc.identifier.uri | http://hdl.handle.net/10451/51034 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Springer Nature | pt_PT |
| dc.relation | Rejuvenating Strategies for Stem Cell-Based Therapies in the Aged Skeletal Muscle | |
| dc.relation.publisherversion | https://www.nature.com/nrm/ | pt_PT |
| dc.title | Control of satellite cell function in muscle regeneration and its disruption in ageing | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardNumber | PTDC/MED-OUT/8010/2020 | |
| oaire.awardTitle | Rejuvenating Strategies for Stem Cell-Based Therapies in the Aged Skeletal Muscle | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-OUT%2F8010%2F2020/PT | |
| oaire.citation.title | Nature Reviews Molecular Cell Biology | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| person.familyName | Sousa-Victor | |
| person.givenName | Pedro | |
| person.identifier.ciencia-id | 7015-9ABE-E82D | |
| person.identifier.orcid | 0000-0002-6521-7839 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 861fc82a-2558-4d7e-ae59-f0d8bb0e064e | |
| relation.isAuthorOfPublication.latestForDiscovery | 861fc82a-2558-4d7e-ae59-f0d8bb0e064e | |
| relation.isProjectOfPublication | f03ae6f4-4b19-4c91-8412-f38ae149feef | |
| relation.isProjectOfPublication.latestForDiscovery | f03ae6f4-4b19-4c91-8412-f38ae149feef |
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