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Transdifferentiation of plasmatocytes to crystal cells in the lymph gland of Drosophila melanogaster

2025-03Artigo científico Acesso aberto
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dc.contributor.authorMarcetteau, Julien
dc.contributor.authorDuarte, Patrícia
dc.contributor.authorLeitão, Alexandre B
dc.contributor.authorSucena, Élio
dc.date.accessioned2025-04-14T12:48:35Z
dc.date.available2025-04-14T12:48:35Z
dc.date.issued2025-03
dc.description.abstractUnder homeostatic conditions, haematopoiesis in Drosophila larvae occurs in the lymph gland and sessile haemocyte clusters to produce two functionally and morphologically different cells: plasmatocytes and crystal cells. It is well-established that in the lymph gland both cell types stem from a binary decision of the medullary prohaemocyte precursors. However, in sessile clusters and dorsal vessel, crystal cells have been shown to originate from the transdifferentiation of plasmatocytes in a Notch/Serrate-dependent manner. We show that transdifferentiation occurs also in the lymph gland. In vivo phagocytosis assays confirm that cortical plasmatocytes are functionally differentiated phagocytic cells. We uncover a double-positive population in the cortical zone that lineage-tracing and long-term live imaging experiments show will differentiate into crystal cells. The reduction of Notch levels within the lymph gland plasmatocyte population reduces crystal cell number. This extension of a transdifferentiation mechanism reinforces the growing role of haematopoietic plasticity in maintaining homeostasis in Drosophila and vertebrate systems. Future work should test the regulation and relative contribution of these two processes under different immunological and/or metabolic conditions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarcetteau, J., Duarte, P., Leitão, A. B., & Sucena, É. (2025). Transdifferentiation of plasmatocytes to crystal cells in the lymph gland of Drosophila melanogaster. EMBO Reports, 1–21. https://doi.org/10.1038/s44319-025-00366-zpt_PT
dc.identifier.doi10.1038/s44319-025-00366-zpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/100196
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Embo Presspt_PT
dc.relationInstituto Gulbenkian de Ciência/Fundação Calouste Gulbenkian and FCT-Fundação para a Ciência e a Tecnologia (Portugal) UIDB/00329/2020 and by C.S. CONGENTO, project LISBOA-01-0145-FEDER-022170, co-financed by Lisboa Regional Operational Programme (Lisboa 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and Foundation for Science and Technology (Portugal)pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleTransdifferentiation of plasmatocytes to crystal cells in the lymph gland of Drosophila melanogasterpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEMBO Reportspt_PT
person.familyNameda Silva Sucena
person.givenNameJosé Élio
person.identifierhttps://scholar.google.com/citations?user=G8IMng8AAAAJ&hl=en
person.identifier.ciencia-id801C-77F5-F8B7
person.identifier.orcid0000-0001-8810-870X
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3b75db45-f117-4d08-9bd3-1dc430e252ec
relation.isAuthorOfPublication.latestForDiscovery3b75db45-f117-4d08-9bd3-1dc430e252ec

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