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Prevalence and risk factors of fatty liver in Portuguese adults

2020-06Artigo científico Acesso restrito
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dc.contributor.authorLeitão, Jorge
dc.contributor.authorCarvalhana, Sofia
dc.contributor.authorCochicho, Joana
dc.contributor.authorSilva, Ana Paula
dc.contributor.authorVelasco, Francisco
dc.contributor.authorMedeiros, Isabel
dc.contributor.authorAlves, Ana Catarina
dc.contributor.authorBourbon, Mafalda
dc.contributor.authorOliveiros, Bárbara
dc.contributor.authorRodrigues, Vitor
dc.contributor.authorSousa, Rita
dc.contributor.authorSampaio, Filipa
dc.contributor.authorCarvalho, Armando
dc.contributor.authorCortez-Pinto, Helena
dc.date.accessioned2020-11-17T13:23:52Z
dc.date.available2020-11-17T13:23:52Z
dc.date.issued2020-06
dc.description© 2020 Stichting European Society for Clinical Investigation Journal Foundationpt_PT
dc.description.abstractBackground: Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. Materials and methods: A cross-sectional, population-based multicenter study, voluntary and randomly selected in 834 Portuguese adults (18-79 years). Participants were evaluated after 12-hour fasting. Anthropometric data, past history including alcohol consumption, and associated diseases were registered. Blood samples were collected for biochemical testing. Dietary intake was evaluated using a semi-quantitative food frequency questionnaire. Presence of FL was evaluated using ultrasound, and NAFLD was diagnosed after exclusion of other causes for liver disease. Results: Adjusted prevalence of FL and NAFLD was 37.8% and 17.0%, respectively. FL individuals were older, more frequently males, with increased probability of having obesity, diabetes or harmful alcohol consumption (HAC). NAFLD individuals were also older, but had a similar sex distribution and an increased probability of obesity and diabetes. In both groups, no differences were found regarding dietary pattern or physical activity. During the same time period, nonalcoholic steatohepatitis (NASH) liver-related deaths in Portugal were 0.105/100 000, while alcohol-related liver disease mortality was 6.790/100 000. Conclusion: The large spectrum of FL was present in more than one third of the population, although only less than half could be classified as NAFLD. Other significant risk factors, such as HAC, are probably implicated in FL, explaining the low NASH-related mortality compared with the high alcohol-related mortality during the same time period.pt_PT
dc.description.sponsorshipThe present study received grants from: Portuguese Association for the Study of the Liver (APEF), Gilead Foundation and Gilead Genesis and Roche supplied laboratorial kits. APEF, Gilead Foundation and Gilead Genesis and Roche had no role in the design, analysis or writing of this article, and in the decision to submit the article for publication.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Clin Invest. 2020 Jun;50(6):e13235.pt_PT
dc.identifier.doi10.1111/eci.13235pt_PT
dc.identifier.eissn1365-2362
dc.identifier.issn0014-2972
dc.identifier.urihttp://hdl.handle.net/10451/44901
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons, Incpt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/13652362pt_PT
dc.subjectAlcohol consumptionpt_PT
dc.subjectDiabetespt_PT
dc.subjectFatty liverpt_PT
dc.subjectMortalitypt_PT
dc.subjectNonalcoholic fatty liverpt_PT
dc.subjectNutritional patternpt_PT
dc.subjectObesitypt_PT
dc.titlePrevalence and risk factors of fatty liver in Portuguese adultspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPagee13235pt_PT
oaire.citation.titleEuropean Journal of Clinical Investigationpt_PT
oaire.citation.volume50pt_PT
person.familyNameSousa
person.familyNameRibeiro Pimenta Sampaio
person.familyNameCortez-Pinto
person.givenNameRita
person.givenNameFilipa de Jesus
person.givenNameHelena
person.identifier.ciencia-id5813-5534-2563
person.identifier.ciencia-idA01C-0511-C986
person.identifier.orcid0000-0002-2163-9343
person.identifier.orcid0000-0002-5540-9853
person.identifier.orcid0000-0002-8537-8744
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4ddae645-996b-4c6a-a0c4-3f126d27bc02
relation.isAuthorOfPublication8eb69b15-6478-4039-9d1c-90aaf09e3997
relation.isAuthorOfPublication91fdb4b3-d491-4e67-94ff-dcf5013fa1a7
relation.isAuthorOfPublication.latestForDiscovery8eb69b15-6478-4039-9d1c-90aaf09e3997

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