Orientador(es)
Resumo(s)
A series of cryptolepine derivatives has been synthesized through the incorporation of short basic side-chains in the C-11 position of the 10H-indolo[3,2-b] quinoline scaffold. Their antiplasmodial activity was evaluated in vitro against the chloroquine resistant Plasmodium falciparum W2 strain, showing IC50 values between 22 and 184 nM, while their cytotoxicity was assessed using HUVEC cells, revealing three compounds with a selectivity ratio higher than 10. The most selective of these derivatives, 4d, with a selectivity ratio of 46, was also the least cytotoxic of the series. (c) 2008 Elsevier Ltd. All rights reserved.
Descrição
Palavras-chave
Chemistry, Medicinal Chemistry, Organic
Contexto Educativo
Citação
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - Vol. 18, n. 4 (FEB 15 2008), p. 1378-1381
Editora
PERGAMON-ELSEVIER SCIENCE LTD