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Elucidating different pattern of immunoregulation in BALB/c and C57BL/6 mice and their F1 progeny

2021Artigo científico Acesso aberto
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dc.contributor.authorHartmann, Wiebke
dc.contributor.authorBlankenhaus, Birte
dc.contributor.authorBrunn, Marie-Luise
dc.contributor.authorMeiners, Jana
dc.contributor.authorBreloer, Minka
dc.date.accessioned2021-02-08T17:53:58Z
dc.date.available2021-02-08T17:53:58Z
dc.date.issued2021
dc.description© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ .pt_PT
dc.description.abstractHelminths are large multicellular parasites that infect one quarter of the human population. To prolong their survival, helminths suppress the immune responses of their hosts. Strongyloides ratti delays its expulsion from the gut by induction of regulatory circuits in a mouse strain-specific manner: depletion of Foxp3+ regulatory T cells (Treg) improves the anti-S. ratti immunity in BALB/c but not in C57BL/6 mice. In the current study we compare the hierarchy of immunoregulatory pathways in BALB/c, C57BL/6 mice and their F1 progeny (BALB/c × C57BL/6). Using multicolor flow cytometry, we show that S. ratti induces a distinct pattern of inhibitory checkpoint receptors by Foxp3+ Treg and Foxp3- T cells. Intensity of expression was highest in C57BL/6 and lowest in BALB/c mice, while the F1 cross had an intermediate phenotype or resembled BALB/c mice. Treg subsets expanded during infection in all three mouse strains. Similar to BALB/c mice, depletion of Treg reduced intestinal parasite burden and increased mucosal mast cell activation in S. ratti-infected F1 mice. Our data indicate that Treg dominate the regulation of immune responses in BALB/c and F1 mice, while multiple regulatory layers exist in C57BL/6 mice that may compensate for the absence of Treg.pt_PT
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep. 2021 Jan 15;11(1):1536pt_PT
dc.identifier.doi10.1038/s41598-020-79477-7pt_PT
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10451/46229
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.nature.com/srep/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleElucidating different pattern of immunoregulation in BALB/c and C57BL/6 mice and their F1 progenypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage1536pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume11pt_PT
person.familyNameBlankenhaus
person.givenNameBirte
person.identifier.ciencia-idFD19-D7A4-E29D
person.identifier.orcid0000-0003-0987-5228
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2d28ba54-99dc-4339-8105-58809bce40c2
relation.isAuthorOfPublication.latestForDiscovery2d28ba54-99dc-4339-8105-58809bce40c2

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