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Host AMPK Is a modulator of Plasmodium liver infection

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dc.contributor.authorRuivo, Margarida
dc.contributor.authorVera, Iset
dc.contributor.authorSales Dias, Joana
dc.contributor.authorMeireles, Patricia
dc.contributor.authorGural, Nil
dc.contributor.authorBhatia, Sangeeta N.
dc.contributor.authorMota, Maria M.
dc.contributor.authorMancio-Silva, Liliana
dc.date.accessioned2022-05-19T14:22:30Z
dc.date.available2022-05-19T14:22:30Z
dc.date.issued2016
dc.description© 2016 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractManipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here, we demonstrate that the opposite is observed in cells infected with rodent malaria parasites. Indeed, AMPK activity upon the infection of hepatic cells is suppressed and dispensable for successful infection. By contrast, an overactive AMPK is deleterious to intracellular growth and replication of different Plasmodium spp., including the human malaria parasite, P. falciparum. The negative impact of host AMPK activity on infection was further confirmed in mice under conditions that activate its function. Overall, this work establishes the role of host AMPK signaling as a suppressive pathway of Plasmodium hepatic infection and as a potential target for host-based antimalarial interventions.pt_PT
dc.description.sponsorshipThis work was supported by European Commission (FP7/2007-2013) grant agreement No. 242095 (EVIMalaR) to L.M.-S. and M.M.M.; and Fundação para a Ciência e Tecnologia (Portugal) through grants PTDC/SAU-MET/118199/2010 and EXCL/IMI-MIC/0056/2012 to L.M.-S. and M.M.M., respectively. M.M.M. was also supported by the ERC (agreement No. 311502). I.M.V. was sponsored by EMBO LTF 712-2012 and NIH NRSA 5F32AI104252 fellowships.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCell Rep. 2016 Sep 6;16(10):2539-2545pt_PT
dc.identifier.doi10.1016/j.celrep.2016.08.001pt_PT
dc.identifier.eissn2211-1247
dc.identifier.issn2639-1856
dc.identifier.urihttp://hdl.handle.net/10451/53069
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationTowards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR).
dc.relationMechanisms of nutrient-sensing by the malaria parasite
dc.relationNutrient sensing by parasites
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/cell-reportspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleHost AMPK Is a modulator of Plasmodium liver infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTowards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR).
oaire.awardTitleMechanisms of nutrient-sensing by the malaria parasite
oaire.awardTitleNutrient sensing by parasites
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/242095/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-MET%2F118199%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXCL%2FIMI-MIC%2F0056%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/311502/EU
oaire.citation.endPage2545pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage2539pt_PT
oaire.citation.titleCell Reportspt_PT
oaire.citation.volume16pt_PT
oaire.fundingStreamFP7
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
person.familyNameRuivo
person.familyNameVera
person.familyNameSales Dias
person.familyNameMeireles
person.familyNameMota
person.familyNameMancio-Silva
person.givenNameMargarida
person.givenNameIset
person.givenNameJoana
person.givenNamePatricia
person.givenNameMaria Manuel
person.givenNameLiliana
person.identifier864685
person.identifier.ciencia-id241E-FF1E-5BD5
person.identifier.ciencia-idF01B-91DA-7C52
person.identifier.ciencia-id4217-0969-297E
person.identifier.orcid0000-0001-8667-9250
person.identifier.orcid0000-0003-4835-9437
person.identifier.orcid0000-0001-8768-4166
person.identifier.orcid0000-0002-9188-2808
person.identifier.orcid0000-0002-2858-1041
person.identifier.orcid0000-0002-5585-018X
person.identifier.ridF-9905-2013
person.identifier.scopus-author-id16308336900
person.identifier.scopus-author-id7102709816
person.identifier.scopus-author-id8866484900
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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