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Structural requirements of glycosaminoglycans for their interaction with HIV-1 envelope glycoprotein gp120

2014Journal article Restricted access
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dc.contributor.authorMatos, Pedro M.
dc.contributor.authorAndreu, David
dc.contributor.authorSantos, Nuno C.
dc.contributor.authorGutiérrez-Gallego, Ricardo
dc.date.accessioned2016-04-27T17:22:30Z
dc.date.available2016-04-27T17:22:30Z
dc.date.issued2014
dc.description© Springer-Verlag Wien 2013pt_PT
dc.description.abstractHeparan sulfate proteoglycans are known to assist HIV-1 entry into host cells, mediated by the viral envelope glycoprotein gp120. We aimed to determine the general structural features of glycosaminoglycans that enable their binding to gp120, by surface plasmon resonance. Binding was found to be dependent on sequence type, size and sulfation patterns. HIV-1 gp120 prefers heparin and heparan sulfate (with at least 16 monomers in length) over chondroitin and dermatan. Sulfate groups were essential to promote this interaction. These results advance the understanding of the molecular-level requirements for virus attachment and cell entry.pt_PT
dc.description.sponsorshipThis work was funded by Fundação para a Ciência e a Tecnologia–Ministério da Educação e Ciência (FCT-MEC, Portugal; projects PTDC/QUI-BIQ/104787/2008 and VIH/SAU/0047/2011, as well as P.M.M. PhD fellowship SFRH/BD/42205/2007) and the Spanish Ministry of Science and Innovation (project BIO2009-08983 to R.G.G.).pt_PT
dc.identifier.citationArch Virol (2014) 159:555–560pt_PT
dc.identifier.doi10.1007/s00705-013-1831-3pt_PT
dc.identifier.issn0304-8608
dc.identifier.urihttp://hdl.handle.net/10451/23553
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationCell membrane features in HIV entry and its inhibition
dc.relationMulti-target HIV entry inhibitors delivery by cationic liposomes
dc.relation.publisherversionhttp://link.springer.com/journal/705pt_PT
dc.subjectHIV-1pt_PT
dc.subjectgp120pt_PT
dc.subjectViral attachmentpt_PT
dc.subjectHeparan sulfate proteoglycanspt_PT
dc.subjectGlycosaminoglycanspt_PT
dc.subjectSurface plasmon resonancept_PT
dc.titleStructural requirements of glycosaminoglycans for their interaction with HIV-1 envelope glycoprotein gp120pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCell membrane features in HIV entry and its inhibition
oaire.awardTitleMulti-target HIV entry inhibitors delivery by cationic liposomes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-BIQ%2F104787%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/VIH%2FSAU%2F0047%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F42205%2F2007/PT
oaire.citation.titleArchives of Virologypt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationaea345fc-1827-44ac-911d-545a3bd497a3
relation.isProjectOfPublicationc2649ab8-aa18-47dc-a765-4a1f94c70549
relation.isProjectOfPublication09f11608-c39b-4aeb-9633-7d2abd162a64
relation.isProjectOfPublication.latestForDiscovery09f11608-c39b-4aeb-9633-7d2abd162a64

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