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Interactions among myeloid regulatory cells in cancer

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dc.contributor.authorUmansky, Viktor
dc.contributor.authorAdema, Gosse J.
dc.contributor.authorBaran, Jaroslaw
dc.contributor.authorBrandau, Sven
dc.contributor.authorVan Ginderachter, Jo A.
dc.contributor.authorHu, Xiaoying
dc.contributor.authorJablonska, Jadwiga
dc.contributor.authorMojsilovic, Slavko
dc.contributor.authorPapadaki, Helen A.
dc.contributor.authorPico de Coaña, Yago
dc.contributor.authorSantegoets, Kim C. M.
dc.contributor.authorSantibanez, Juan F.
dc.contributor.authorSerre, Karine
dc.contributor.authorSi, Yu
dc.contributor.authorSieminska, Isabela
dc.contributor.authorVelegraki, Maria
dc.contributor.authorFridlender, Zvi G.
dc.date.accessioned2021-02-19T17:57:36Z
dc.date.available2021-02-19T17:57:36Z
dc.date.issued2018
dc.description© Springer-Verlag GmbH Germany, part of Springer Nature 2018pt_PT
dc.description.abstractMounting evidence has accumulated on the critical role of the different myeloid cells in the regulation of the cancerous process, and in particular in the modulation of the immune reaction to cancer. Myeloid cells are a major component of host cells infiltrating tumors, interacting with each other, with tumor cells and other stromal cells, and demonstrating a prominent plasticity. We describe here various myeloid regulatory cells (MRCs) in mice and human as well as their relevant therapeutic targets. We first address the role of the monocytes and macrophages that can contribute to angiogenesis, immunosuppression and metastatic dissemination. Next, we discuss the differential role of neutrophil subsets in tumor development, enhancing the dual and sometimes contradicting role of these cells. A heterogeneous population of immature myeloid cells, MDSCs, was shown to be generated and accumulated during tumor progression as well as to be an important player in cancer-related immune suppression. Lastly, we discuss the role of myeloid DCs, which can either contribute to effective anti-tumor responses or play a more regulatory role. We believe that MRCs play a critical role in cancer-related immune regulation and suggest that future anti-cancer therapies will focus on these abundant cells.pt_PT
dc.description.sponsorshipThis work was supported by COST (European Cooperation in Science and Technology) and the COST Action BM1404 Mye-EUNITER (http://www.mye-eunit er.eu). COST is part of the EU Framework Programme Horizon 2020. This work was also supported by Grants from the Cooperation between German Cancer Research Center (DKFZ) and Ministry of Science, Technology and Space of Israel (MOST) in Cancer Research (CA181 to V. Umansky and Z.G. Fridlender).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCancer Immunol Immunother. 2019 Apr;68(4):645-660pt_PT
dc.identifier.doi10.1007/s00262-018-2200-6pt_PT
dc.identifier.eissn1432-0851
dc.identifier.issn0340-7004
dc.identifier.urihttp://hdl.handle.net/10451/46448
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/262pt_PT
dc.subjectMyeloid regulatory cellspt_PT
dc.subjectMye-EUNITERpt_PT
dc.subjectMacrophagespt_PT
dc.subjectNeutrophilspt_PT
dc.subjectMyeloid-derived suppressor cellspt_PT
dc.subjectDendritic cellspt_PT
dc.titleInteractions among myeloid regulatory cells in cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage660pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage645pt_PT
oaire.citation.titleCancer Immunology, Immunotherapypt_PT
oaire.citation.volume68pt_PT
person.familyNameSerre
person.givenNameKarine
person.identifier120366
person.identifier.ciencia-id1E11-7283-DF35
person.identifier.orcid0000-0001-9152-4739
person.identifier.scopus-author-id6602493849
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationca6a906a-8017-40b3-9692-8c72c063c339
relation.isAuthorOfPublication.latestForDiscoveryca6a906a-8017-40b3-9692-8c72c063c339

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