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Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder

2021Artigo científico Acesso aberto
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dc.contributor.authorGomes, Joana I.
dc.contributor.authorFarinha Ferreira, Jorge Miguel
dc.contributor.authorRei, Nádia
dc.contributor.authorGonçalves-Ribeiro, Joana
dc.contributor.authorRibeiro, Joaquim A.
dc.contributor.authorSebastião, Ana M
dc.contributor.authorVaz, Sandra H.
dc.date.accessioned2021-04-06T11:54:09Z
dc.date.available2021-04-06T11:54:09Z
dc.date.issued2021
dc.description© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractMajor depressive disorder (MDD) is the foremost cause of global disability, being responsible for enormous personal, societal, and economical costs. Importantly, existing pharmacological treatments for MDD are partially or totally ineffective in a large segment of patients. As such, the search for novel antidepressant drug targets, anchored on a clear understanding of the etiological and pathophysiological mechanisms underpinning MDD, becomes of the utmost importance. The adenosinergic system, a highly conserved neuromodulatory system, appears as a promising novel target, given both its regulatory actions over many MDD-affected systems and processes. With this goal in mind, we herein review the evidence concerning the role of adenosine as a potential player in pathophysiology and treatment of MDD, combining data from both human and animal studies. Altogether, evidence supports the assertions that the adenosinergic system is altered in both MDD patients and animal models, and that drugs targeting this system have considerable potential as putative antidepressants. Furthermore, evidence also suggests that modifications in adenosine signaling may have a key role in the effects of several pharmacological and non-pharmacological antidepressant treatments with demonstrated efficacy, such as electroconvulsive shock, sleep deprivation, and deep brain stimulation. Lastly, it becomes clear from the available literature that there is yet much to study regarding the role of the adenosinergic system in the pathophysiology and treatment of MDD, and we suggest several avenues of research that are likely to prove fruitful.pt_PT
dc.description.sponsorshipThis work was supported by project funding from Fundação para a Ciência e para a Tecnologia (FCT) to SHV (PTDC/BTM-SAL/32147/2017) and AMS (PTDC/MED-FAR/30933/2017). This project has received funding from H2020-WIDESPREAD-05-2017-Twinning (EpiEpinet) under grant agreement No. 952455. MF-F (SFRH/BD/147505/2019), JG-R (PD/BD/150342/2019), and NR (PD/BD/113463/2015) are supported by PhD fellowships from FCT.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPharmacol Res. 2021 Jan;163:105363pt_PT
dc.identifier.doi10.1016/j.phrs.2020.105363pt_PT
dc.identifier.eissn1096-1186
dc.identifier.issn1043-6618
dc.identifier.urihttp://hdl.handle.net/10451/47247
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAstrosomes: Artificial Astrocytes as a Novel Approach to Regulate Neuronal Communication
dc.relationIn the search of the synaptic mechanism operated by a novel selective antiepileptic drug
dc.relationEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
dc.relationLess may be more: potential procognitive and antidepressant effects of sub-hallucinogenic psilocybin doses in an animal model of depression
dc.relationA definir
dc.relationCharacterization of neuromodulatory dysfunction in Amyotrophic Lateral Sclerosis ALS.
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/pharmacological-researchpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdenosinept_PT
dc.subjectAdenosinergic systempt_PT
dc.subjectAntidepressantspt_PT
dc.subjectAnxietypt_PT
dc.subjectMajor Depressive Disorderpt_PT
dc.titleOf adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAstrosomes: Artificial Astrocytes as a Novel Approach to Regulate Neuronal Communication
oaire.awardTitleIn the search of the synaptic mechanism operated by a novel selective antiepileptic drug
oaire.awardTitleEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
oaire.awardTitleLess may be more: potential procognitive and antidepressant effects of sub-hallucinogenic psilocybin doses in an animal model of depression
oaire.awardTitleA definir
oaire.awardTitleCharacterization of neuromodulatory dysfunction in Amyotrophic Lateral Sclerosis ALS.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTM-SAL%2F32147%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-FAR%2F30933%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/952455/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F147505%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F150342%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F113463%2F2015/PT
oaire.citation.titlePharmacological Researchpt_PT
oaire.citation.volume163pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamH2020
oaire.fundingStreamOE
oaire.fundingStreamOE
person.familyNameGomes
person.familyNameFarinha Ferreira
person.familyNameHenriques Rei
person.familyNameGonçalves Ribeiro
person.familyNameSebastião
person.familyNameHenriques Vaz
person.givenNameJoana I.
person.givenNameJorge Miguel
person.givenNameNádia Raquel
person.givenNameJoana Filipa
person.givenNameAna M
person.givenNameSandra Cristina
person.identifier694933
person.identifier.ciencia-id7A17-D40A-D6F5
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person.identifier.ciencia-idF112-55E8-E37E
person.identifier.ciencia-id0E1C-952D-61BE
person.identifier.orcid0000-0001-7761-1983
person.identifier.orcid0000-0003-1240-0717
person.identifier.orcid0000-0003-0131-0126
person.identifier.orcid0000-0002-5194-6512
person.identifier.orcid0000-0001-9030-6115
person.identifier.orcid0000-0003-4258-9397
person.identifier.scopus-author-id7004409879
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.typearticlept_PT
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