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circRNA-miRNA cross-talk in the transition from paroxysmal to permanent atrial fibrillation

2019-09-01Artigo científico Acesso restrito
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dc.contributor.authorCosta, Marina C.
dc.contributor.authorCortez-Dias, Nuno
dc.contributor.authorGabriel, André F.
dc.contributor.authorDe Sousa, João
dc.contributor.authorFiuza, Manuela
dc.contributor.authorGallego, Javier
dc.contributor.authorNobre, Ângelo
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorEnguita, Francisco J.
dc.date.accessioned2019-07-16T13:52:14Z
dc.date.available2019-07-16T13:52:14Z
dc.date.issued2019-09-01
dc.description© 2019 Elsevier B.V. All rights reserved.pt_PT
dc.description.abstractBackground: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in western countries. The factors governing the progression of AF to a permanent chronic condition are still not well characterized. Among epigenetic factors, non-coding RNAs (ncRNAs) such as miRNAs and lncRNAs have been recently described as important players involved in the AF progression. We hypothesize about the existence of additional regulatory layers in AF involving an intricate cross-talk between different ncRNA species, namely miRNAs and circRNAs for the establishment of a chronic AF condition. Methods and results: We have performed an unbiased study analyzing the expression profile for miRNAs and circRNAs in left-atrial biopsies from patients with paroxysmal and permanent AF by RNA-seq. The transition from paroxysmal to permanent AF is characterized by a pattern of down-regulated miRNAs, concomitant to the appearance of specific circRNA species. The analysis of the sponging activities of the circRNAs exclusively expressed in permanent AF samples, allowed us to determine that they could be responsible for the downregulation of specific miRNAs in establishment of a permanent AF condition. Conclusion: Sponging activity of circRNAs sequestering specific miRNAs is an important factor to be considered for the determination of the molecular mechanisms involved in AF progression.pt_PT
dc.description.sponsorshipThe present research work has been performed with the support of the Fundação para a Ciência e a Tecnologia (FCT), research grant PTDC-MED-GEN-29389-2017.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Cardiol. 2019 Sep 1;290:134-137pt_PT
dc.identifier.doi10.1016/j.ijcard.2019.04.072pt_PT
dc.identifier.issn0167-5273
dc.identifier.urihttp://hdl.handle.net/10451/39126
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPTDC-MED-GEN-29389-2017pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/international-journal-of-cardiologypt_PT
dc.subjectAtrial fibrillationpt_PT
dc.subjectCircular RNAspt_PT
dc.subjectMicro-RNAspt_PT
dc.subjectRegulatory networkspt_PT
dc.subjectRNAseqpt_PT
dc.titlecircRNA-miRNA cross-talk in the transition from paroxysmal to permanent atrial fibrillationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage137pt_PT
oaire.citation.startPage134pt_PT
oaire.citation.titleInternational Journal of Cardiologypt_PT
oaire.citation.volume290pt_PT
person.familyNameCosta
person.familyNameCortez-Dias
person.familyNameGabriel
person.familyNamede Sousa
person.familyNameFiuza
person.familyNamePinto
person.familyNameEnguita
person.givenNameMarina
person.givenNameNuno
person.givenNameAndré Filipe Gonçalves
person.givenNameJoão
person.givenNameManuela
person.givenNameFausto J.
person.givenNameFrancisco J.
person.identifier887495
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person.identifier.ciencia-idB215-8D49-3218
person.identifier.orcid0000-0001-9020-7539
person.identifier.orcid0000-0002-9244-4631
person.identifier.orcid0000-0002-6565-1600
person.identifier.orcid0000-0003-2782-8214
person.identifier.orcid0000-0002-7742-6195
person.identifier.orcid0000-0002-8034-4529
person.identifier.orcid0000-0002-8072-8557
person.identifier.ridO-1710-2014
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person.identifier.scopus-author-id55453276400
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person.identifier.scopus-author-id6701659391
person.identifier.scopus-author-id7102740158
person.identifier.scopus-author-id6602119231
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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