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Commonality of multidrug-resistant klebsiella pneumoniae ST348 isolates in horses and humans in Portugal

2019-07-10Artigo científico Acesso aberto
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dc.contributor.authorTrigo Da Roza, Filipa
dc.contributor.authorCouto, Natacha
dc.contributor.authorCarneiro, Carla
dc.contributor.authorCunha, Eva
dc.contributor.authorRosa, Teresa
dc.contributor.authorMagalhães, Mariana
dc.contributor.authorTavares, Luis
dc.contributor.authorNovais, Ângela
dc.contributor.authorPeixe, Luísa
dc.contributor.authorLamas, Luís P.
dc.contributor.authorOliveira, Manuela
dc.date.accessioned2021-06-03T18:52:54Z
dc.date.available2021-06-03T18:52:54Z
dc.date.issued2019-07-10
dc.descriptionMicrobiologiapt_PT
dc.descriptionMicrobiologypt_PT
dc.description.abstractABSTRACT - Multidrug-resistant (MDR) Klebsiella pneumoniae is considered a major global concern by the World Health Organization. Evidence is growing on the importance of circulation of MDR bacterial populations between animals and humans. Horses have been shown to carry commensal isolates of this bacterial species and can act as human MDR bacteria reservoirs. In this study, we characterized an extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae sequence type (ST) 348 isolate from a horse, an ST reported for the first time in an animal, using next-generation sequencing. We compared it with six other MDR K. pneumoniae ST348 human isolates previously identified in health-care facilities in Portugal using a core genome multi-locus sequence typing approach to evaluate a possible genetic link. The horse isolate was resistant to most of the antimicrobials tested, including 3rd generation cephalosporins, fluoroquinolones, and aminoglycosides, and presented several antimicrobial resistance genes, including blaESBL. Twenty-one allele differences were found between the horse isolate and the most similar human isolate, suggesting a recent common ancestor. Other similarities were observed regarding the content on antimicrobial resistance genes, plasmid incompatibility groups, and capsular and somatic antigens. This study illustrates the relevance of the dissemination of MDR strains, and enhances that identification of these types of bacterial strains in both human and veterinary settings is of significant relevance in order to understand and implement combined control strategies for MDR bacteria in animals and humans.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTrigo da Roza, F., Couto, N., Carneiro, C., Cunha, E., Rosa, T., Magalhães, M., Tavares, L., Novais, Â., Peixe, L., Rossen, J. W., Lamas, L. P., & Oliveira, M. 2019. Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal [article]. Frontiers in Microbiology, 10, [1657], p. 1-10. Doi:10.3389/fmicb.2019.01657pt_PT
dc.identifier.doi10.3389/fmicb.2019.01657pt_PT
dc.identifier.issn1664302X
dc.identifier.urihttp://hdl.handle.net/10400.5/21425
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media S.A.pt_PT
dc.relationU/ID/CVT/276/2019pt_PT
dc.relationPrevention of periodontal disease in dogs: an experimental approach using an antimicrobial peptide
dc.relation.publisherversionhttps://pure.rug.nl/ws/files/96180710/fmicb_10_01657.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobial resistancept_PT
dc.subjectESBLpt_PT
dc.subjectHorsept_PT
dc.subjectKlebsiella pneumoniaept_PT
dc.subjectST348pt_PT
dc.subjectEscherichia-colipt_PT
dc.subjectInfectionspt_PT
dc.subjectAnimalspt_PT
dc.subjectClonespt_PT
dc.titleCommonality of multidrug-resistant klebsiella pneumoniae ST348 isolates in horses and humans in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePrevention of periodontal disease in dogs: an experimental approach using an antimicrobial peptide
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F131384%2F2017/PT
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Microbiologypt_PT
oaire.citation.volumev.10pt_PT
person.familyNameTrigo da Roza
person.familyNameCouto
person.familyNameGonçalves da Cunha
person.familyNameMorgado Tavares
person.familyNameOliveira
person.givenNameFilipa
person.givenNameNatacha
person.givenNameEva Sofia
person.givenNameLuis Manuel
person.givenNameManuela
person.identifier633700
person.identifier376478
person.identifier.ciencia-idA41D-FD78-89EF
person.identifier.ciencia-id9811-7B6B-E2B9
person.identifier.ciencia-id9011-18C6-482D
person.identifier.ciencia-idBE1E-2B3B-92D2
person.identifier.orcid0000-0002-8345-0415
person.identifier.orcid0000-0002-9152-5464
person.identifier.orcid0000-0002-5641-4400
person.identifier.orcid0000-0001-8671-6285
person.identifier.orcid0000-0002-3910-1525
person.identifier.ridU-9872-2018
person.identifier.scopus-author-id36614104700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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