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Evolution of the concepts of endometrosis, post breeding endometritis, and susceptibility of mares

2022-03-19Artigo científico Acesso aberto
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dc.contributor.authorKatila, Terttu
dc.contributor.authorFerreira-Dias, Graça
dc.date.accessioned2022-05-09T22:51:11Z
dc.date.available2022-05-09T22:51:11Z
dc.date.issued2022-03-19
dc.descriptionResearch Areas: Agriculture ; Veterinary Sciences ; Zoologypt_PT
dc.description.abstractIn this paper, the evolution of our understanding about post breeding endometritis (PBE), the susceptibility of mares, and events leading to endometrosis are reviewed. When sperm arrive in the uterus, pro-inflammatory cytokines and chemokines are released. They attract neutrophils and induce modulatory cytokines which control inflammation. In susceptible mares, this physiological defense can be prolonged since the pattern of cytokine release differs from that of resistant mares being delayed and weaker for anti-inflammatory cytokines. Delayed uterine clearance due to conformational defects, deficient myometrial contractions, and failure of the cervix to relax is detected by intrauterine fluid accumulation and is an important reason for susceptibility to endometritis. Multiparous aged mares are more likely to be susceptible. Untreated prolonged PBE can lead to bacterial or fungal endometritis called persistent or chronic endometritis. Exuberant or prolonged neutrophilia and cytokine release can have deleterious and permanent effects in inducing endometrosis. Interactions of neutrophils, cytokines, and prostaglandins in the formation of collagen and extracellular matrix in the pathogenesis of fibrosis are discussed. Endometritis and endometrosis are interconnected, influencing each other. It is suggested that they represent epigenetic changes induced by age and hostile uterine environmentpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationKatila T, Ferreira-Dias G. 2022. Evolution of the concepts of endometrosis, post breeding endometritis, and susceptibility of mares. Animals, 12(6):779. Doi 10.3390/ani12060779pt_PT
dc.identifier.doi10.3390/ani12060779pt_PT
dc.identifier.issn2076-2615
dc.identifier.urihttp://hdl.handle.net/10400.5/24266
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-2615/12/6/779pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMarept_PT
dc.subjectBreedingpt_PT
dc.subjectEndometritispt_PT
dc.subjectEndometrosispt_PT
dc.subjectInflammationpt_PT
dc.subjectFibrosispt_PT
dc.subjectNeutrophilspt_PT
dc.subjectCytokinespt_PT
dc.titleEvolution of the concepts of endometrosis, post breeding endometritis, and susceptibility of marespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.titleAnimalspt_PT
oaire.citation.volume12(6):779pt_PT
person.familyNameLeitão Ferreira-Dias
person.givenNameGraça Maria
person.identifier.ciencia-idF51C-7F45-C720
person.identifier.orcid0000-0003-0622-6513
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0fb8ec33-7ee1-482b-bdcb-eff773226f90
relation.isAuthorOfPublication.latestForDiscovery0fb8ec33-7ee1-482b-bdcb-eff773226f90

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