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Genomic epidemiology sheds light on the emergence and spread of Mycobacterium bovis Eu2 Clonal Complex in Portugal

2023-09Artigo científico Acesso aberto
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dc.contributor.authorPereira, André C.
dc.contributor.authorReis, Ana C.
dc.contributor.authorCunha, Mónica V.
dc.date.accessioned2023-10-04T17:28:55Z
dc.date.available2023-10-04T17:28:55Z
dc.date.issued2023-09
dc.description.abstractAnimal tuberculosis (TB) remains a serious concern for animal and human health. Mycobacterium bovis circulates in multi-host systems, dominated by the European 2 clonal complex (Eu2) in Iberia. In this work, we use genomic epidemiology to infer the emergence, spread, and spatiotemporal patterns of Eu2 in the official epidemiological risk area of animal TB in Portugal. Phylogenetic analysis of 144 M. bovis whole-genome sequences from cattle, wild boar, and red deer, representing the 2002–2021 period, distinguished three Eu2 clades that evolved independently. The major Eu2 clade underwent phylodynamic inferences to estimate the time and location of outbreaks, host transitions, and spatial diffusion as well. The origin of this Eu2 clade was attributed to the red deer population in the Castelo Branco district, near the border with Spain. Most host transitions were intraspecific (80%), while interspecific transmissions between wildlife species (wild boar-red deer), and between wild boar and cattle, were highly supported. Phylogeographic reconstruction evidenced that most transitions (82%) occur within municipalities, highlighting local transmission corridors. Our study indicates that M. bovis continues to spread at the cattle-wildlife interface within the animal TB hotspot area, possibly driven by the foraging behaviour of wild boar near agricultural lands. Red deer seems to be an important driver of TB within wildlife hosts, while the wild boar links the multi-host wildlife community and livestock. This work highlights the value of combining genomic epidemiology with phylodynamic inference to resolve host jumps and spatial patterns of M. bovis, providing real-time clues about points of interventionpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAndré C. Pereira, Ana C. Reis & Mónica V. Cunha (2023) Genomic epidemiology sheds light on the emergence and spread of Mycobacterium bovis Eu2 Clonal Complex in Portugal, Emerging Microbes & Infections, 12:2, DOI: 10.1080/22221751.2023.2253340pt_PT
dc.identifier.doi10.1080/22221751.2023.2253340pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/59556
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationFCT PTDC / CVT-CVT / 29783/2017pt_PT
dc.relationFCT UIDB/00329/2020 (cE3c)pt_PT
dc.relationFCT SFRH/BD/136557/2018pt_PT
dc.relationFCT UIDB/04046/2020 (BioISI)pt_PT
dc.relationFCT Associate Laboratory CHANGE (LA/P/0121/2020)pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleGenomic epidemiology sheds light on the emergence and spread of Mycobacterium bovis Eu2 Clonal Complex in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.titleEmerging Microbes & Infectionspt_PT
oaire.citation.volume12pt_PT
person.familyNameC Reis
person.familyNameCunha
person.givenNameAna
person.givenNameMonica V.
person.identifier348477
person.identifier.ciencia-id9D1C-8B26-6DD5
person.identifier.ciencia-id5616-E715-2F31
person.identifier.orcid0000-0001-9250-7842
person.identifier.orcid0000-0003-0401-0276
person.identifier.ridV-3465-2017
person.identifier.ridD-5544-2011
person.identifier.scopus-author-id57212107806
person.identifier.scopus-author-id7102711216
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationba5bfb96-d629-4101-804c-0455cc4ca371
relation.isAuthorOfPublicationa1b365bb-7421-4bf5-9cde-62b74c170e69
relation.isAuthorOfPublication.latestForDiscoverya1b365bb-7421-4bf5-9cde-62b74c170e69

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