Modeling the immune response to HIV infection

Conway, Jessica M.; Ribeiro, Ruy M.

http://hdl.handle.net/10451/45109

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Autores

Conway, Jessica M.

Ribeiro, Ruy M.

Resumo(s)

The interplay between immune response and HIV is intensely studied via mathematical modeling, with significant insights but few direct answers. In this short review, we highlight advances and knowledge gaps across different aspects of immunity. In particular, we identify the innate immune response and its role in priming the adaptive response as ripe for modeling. The latter have been the focus of most modeling studies, but we also synthesize key outstanding questions regarding effector mechanisms of cellular immunity and development of broadly neutralizing antibodies. Thus far, most modeling studies aimed to infer general immune mechanisms; we foresee that significant progress will be made next by detailed quantitative fitting of models to data, and prediction of immune responses.

Descrição

URI

http://hdl.handle.net/10451/45109

Citação

Curr Opin Syst Biol. 2018 Dec;12:61-69

Editora

Elsevier

DOI

10.1016/j.coisb.2018.10.006

Coleções

FM-IMPSP-Artigos em Revistas Internacionais

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