Repository logo
 
Publication

Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection

2024Journal article Restricted access
Simple item page
dc.contributor.authorPedroso, Rodrigo B.
dc.contributor.authorTorres, Lícia
dc.contributor.authorVentura, Lucas Araújo
dc.contributor.authorCamatta, Giovanna Caliman
dc.contributor.authorMota, Catarina
dc.contributor.authorMendes, Ana Catarina
dc.contributor.authorRibeiro, Filipa
dc.contributor.authorGuimarães, Henrique Cerqueira
dc.contributor.authorBarbuto, Rafael Calvão
dc.contributor.authorCaixeta, Felipe
dc.contributor.authorNascimento, Leandro Souza
dc.contributor.authorOliveira, Mariana Almeida
dc.contributor.authorMartins, Vinícius Dantas
dc.contributor.authorSilveira-Nunes, Gabriela
dc.contributor.authorTupinambás, Unaí
dc.contributor.authorTeixeira-Carvalho, Andrea
dc.contributor.authorGraca, Luis
dc.contributor.authorFaria, Ana Maria Caetano
dc.date.accessioned2024-12-11T15:45:35Z
dc.date.available2024-12-11T15:45:35Z
dc.date.issued2024
dc.description© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved.pt_PT
dc.description.abstractRisk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-CoV-2 infection. Among the reasons for this markedly unfavorable response in the elderly, immunosenescence and inflammaging appear as major drivers of this outcome. A finding that was also notable was that hospitalized patients with severe COVID-19 have an accumulation of senescent T cells, suggesting that immunosenescence may be aggravated by SARS-CoV-2 infection. The present work was designed to examine whether these immunosenescence changes are characteristic of COVID-19 and whether it is dependent on disease severity using cross-sectional and longitudinal studies. Our cross-sectional data show that COVID-19, but not other respiratory infections, rapidly increased cellular senescence and exhaustion in CD4 and CD8 T cells during early infection. In addition, longitudinal analyses with patients from Brazil and Portugal provided evidence of increased frequencies of senescent and exhausted T cells over a 7-d period in patients with mild/moderate and severe COVID-19. Altogether, the study suggests that accelerated immunosenescence in CD4 and especially CD8 T-cell compartments may represent a common and unique outcome of SARS-CoV2 infection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Leukoc Biol. 2024 Nov 27;116(6):1385-1397pt_PT
dc.identifier.doi10.1093/jleuko/qiae180pt_PT
dc.identifier.eissn1938-3673
dc.identifier.issn0741-5400
dc.identifier.urihttp://hdl.handle.net/10400.5/96232
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttps://academic.oup.com/jleukbiopt_PT
dc.subjectCOVID-19pt_PT
dc.subjectT-cell exhaustionpt_PT
dc.subjectT-cell senescencept_PT
dc.subjectImmunosenescencept_PT
dc.subjectInflammagingpt_PT
dc.subjectInflammatory cytokinespt_PT
dc.titleRapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1397pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1385pt_PT
oaire.citation.titleJournal of Leukocyte Biologypt_PT
oaire.citation.volume116pt_PT
person.familyNameBalsinha Pedroso
person.familyNameMota da Silva
person.familyNameRibeiro
person.familyNameSilva Graca
person.givenNameRodrigo
person.givenNameMaria Catarina
person.givenNameFilipa
person.givenNameLuis Ricardo
person.identifierB-8887-2008
person.identifier.ciencia-id8A12-48BA-AD4B
person.identifier.ciencia-idCC13-C7B0-19F5
person.identifier.ciencia-id6916-485D-36C3
person.identifier.ciencia-id6C19-B162-F561
person.identifier.orcid0000-0001-6266-8100
person.identifier.orcid0000-0002-4006-7328
person.identifier.orcid0000-0001-6935-8500
person.identifier.ridS-1079-2018
person.identifier.scopus-author-id36138488700
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb657bbf1-7dc4-43e0-a92c-773c9955b397
relation.isAuthorOfPublication293e52d4-2c20-4307-aa27-680d2400bb6b
relation.isAuthorOfPublication45abc672-83ac-42b0-97d5-06f5633530f8
relation.isAuthorOfPublication9da841d6-508a-484b-a61e-ee2fab2bc226
relation.isAuthorOfPublication.latestForDiscovery9da841d6-508a-484b-a61e-ee2fab2bc226

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Rapid_progression.pdf
Size:
1.27 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais