Logo do repositório
 
Publicação

Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

2014-03-27Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorAguiar, Sandra I
dc.contributor.authorBrito, M. J.
dc.contributor.authorHoracio, A. N.
dc.contributor.authorLopes, J. P.
dc.contributor.authorRamirez, Mário
dc.contributor.authorCristino, José Melo
dc.date.accessioned2021-07-26T14:44:22Z
dc.date.available2021-07-26T14:44:22Z
dc.date.issued2014-03-27
dc.descriptionEurosurveillance. © 2007 - 2021. All rights reservedpt_PT
dc.description.abstractThe 10-valent pneumococcal conjugate vaccine (PCV10) became available in Portugal in mid-2009 and the 13-valent vaccine (PCV13) in early 2010. The incidence of invasive pneumococcal disease (IPD) in patients aged under 18 years decreased from 8.19 cases per 100,000 in 2008–09 to 4.52/100,000 in 2011–12. However, IPD incidence due to the serotypes included in the 7-valent conjugate vaccine (PCV7) in children aged under two years remained constant. This fall resulted from significant decreases in the number of cases due to: (i) the additional serotypes included in PCV10 and PCV13 (1, 5, 7F; from 37.6% to 20.6%), particularly serotype 1 in older children; and (ii) the additional serotypes included in PCV13 (3, 6A, 19A; from 31.6% to 16.2%), particularly serotype 19A in younger children. The decrease in serotype 19A before vaccination indicates that it was not triggered by PCV13 administration. The decrease of serotype 1 in all groups, concomitant with the introduction of PCV10, is also unlikely to have been triggered by vaccination, although PCVs may have intensified and supported these trends. PCV13 serotypes remain major causes of IPD, accounting for 63.2% of isolates recovered in Portugal in 2011–12, highlighting the potential role of enhanced vaccination in reducing paediatric IPD in Portugal.pt_PT
dc.description.sponsorshipS.I. Aguiar and A.N. Horácio were supported by grants SFRH/BPD/78376/2011and SFRH/BD/81205/2011, respectively, from Fundação para a Ciência e Tecnologia, Portugal. This work was partially supported by Fundação para a Ciência e Tecnologia, Portugal (PTDC/DTP-EPI/1759/2012) and unrestricted research grants from Pfizer and GlaxoSmithKline.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuro Surveill. 2014 Mar 27;19(12):20750pt_PT
dc.identifier.doi10.2807/1560-7917.es2014.19.12.20750pt_PT
dc.identifier.eissn1025-496X
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10451/49122
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEuropean Centre for Disease Prevention and Controlpt_PT
dc.relation“Development of immunoliposomal therapy for treatment of Pneumococcal meningitis.”
dc.relationCHANGING PNEUMOCOCCAL POPULATION IN ADULTS AS A CONSEQUENCE OF DIFFERENT VACCINATION STRATEGIES
dc.relationBesieged by conjugate vaccination: changes in the pneumococcal population and their genomic consequences
dc.relation.publisherversionhttps://www.eurosurveillance.org/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleDecreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BPD/78376/2011
oaire.awardNumberSFRH/BD/81205/2011
oaire.awardNumberPTDC/DTP-EPI/1759/2012
oaire.awardTitle“Development of immunoliposomal therapy for treatment of Pneumococcal meningitis.”
oaire.awardTitleCHANGING PNEUMOCOCCAL POPULATION IN ADULTS AS A CONSEQUENCE OF DIFFERENT VACCINATION STRATEGIES
oaire.awardTitleBesieged by conjugate vaccination: changes in the pneumococcal population and their genomic consequences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F78376%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F81205%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F1759%2F2012/PT
oaire.citation.issue12pt_PT
oaire.citation.titleEuro Surveillance : European Communicable Disease Bulletinpt_PT
oaire.citation.volume19pt_PT
oaire.fundingStreamOE
oaire.fundingStreamOE
oaire.fundingStream3599-PPCDT
person.familyNameAguiar
person.familyNameRamos de Almeida Ramirez
person.familyNameMelo Cristino
person.givenNameSandra
person.givenNameMário Nuno
person.givenNameJosé
person.identifierA-3500-2009
person.identifierB-4993-2008
person.identifier.ciencia-id8E10-C536-8517
person.identifier.ciencia-id9C1C-F2A2-4226
person.identifier.ciencia-id871E-6AD6-F37C
person.identifier.orcid0000-0002-3041-383X
person.identifier.orcid0000-0002-4084-6233
person.identifier.orcid0000-0001-8643-1722
person.identifier.ridH-3726-2013
person.identifier.scopus-author-id7201568476
person.identifier.scopus-author-id7004053640
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1f00a74a-0d59-471e-b90f-8129ea4558cd
relation.isAuthorOfPublication4fd54543-2f86-41cd-aafa-bc6e6501471d
relation.isAuthorOfPublicationacefbfd7-46d0-4429-80b1-ad159fe4ca95
relation.isAuthorOfPublication.latestForDiscovery1f00a74a-0d59-471e-b90f-8129ea4558cd
relation.isProjectOfPublication12880295-a147-4932-ae3a-275283235d21
relation.isProjectOfPublication016ce0d0-e678-4913-a278-2a3556c092f8
relation.isProjectOfPublication4e5a2d91-0539-4492-86db-672437ecab72
relation.isProjectOfPublication.latestForDiscovery4e5a2d91-0539-4492-86db-672437ecab72

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Decreasing_incidence.pdf
Tamanho:
308.99 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais