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Alterations on peripheral blood B-cell subpopulations in very early arthritis patients

2010-03-07Artigo científico Acesso restrito
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dc.contributor.authorMoura, Rita A.
dc.contributor.authorWeinmann, Pamela
dc.contributor.authorPereira, Patrícia A.
dc.contributor.authorCaetano-Lopes, Joana
dc.contributor.authorCanhao, Helena
dc.contributor.authorSousa, Elsa
dc.contributor.authorMourão, Ana F.
dc.contributor.authorRodrigues, Ana M.
dc.contributor.authorQueiroz, Mário V.
dc.contributor.authorSouto-Carneiro, Maria M.
dc.contributor.authorGraca, Luis
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2012-04-16T15:23:29Z
dc.date.available2012-04-16T15:23:29Z
dc.date.issued2010-03-07
dc.description©The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.eng
dc.description.abstractObjective. To characterize circulating B-cell subpopulations of arthritis patients with <6 weeks of disease duration. Methods. Peripheral blood samples were collected from very early untreated polyarthritis patients, with <6 weeks of disease duration, for flow cytometric evaluation of B-cell subpopulations. Samples from patients who were later diagnosed as RA [very early RA (VERA)] were also collected 4–6 weeks after starting a low dose of prednisone (5–10 mg) and 4 months after reaching the minimum effective dose of MTX. A matched healthy group was used as a control. Results. VERA patients have a lower percentage of total peripheral blood memory B cells (CD19+CD27+) and a significant decrease in the frequency of circulating pre-switch memory B cells (CD19+IgD+CD27+) as compared with controls. Therapy with corticosteroids or MTX was unable to restore the normal frequencies of these B-cell subpopulations. A significant decrease in peripheral pre-switch memory B cells is equally observed in other early arthritis patients. Furthermore, no significant differences are found in the frequencies of CD4+ and CD8+ T cells in all patient groups. Conclusions. In very early polyarthritis patients, there is a reduction in circulating pre-switch memory B cells. The reasons that may account for this effect are still unknown. Short-term corticosteroids and MTX do not seem to have a direct effect on circulating B-cell subpopulations in VERA patients.eng
dc.description.sponsorshipThis work was supported by a grant from Sociedade Portuguesa de Reumatologia/Schering- Plough 2005. R.A.M. was funded by Fundação para a Ciência e Tecnologia (FCT) SFRH/BD/30247/2006, and M.M.S.-C. by Marie Curie Intra-European Fellowship LIF-025885 and a EULAR Young Investigator Award.eng
dc.identifier.citationRheumatology 2010;49:1082–1092por
dc.identifier.issn1462-0324
dc.identifier.urihttp://hdl.handle.net/10451/5992
dc.identifier.uridoi:10.1093/rheumatology/keq029
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherOxford University Presspor
dc.subjectRheumatoid arthritiseng
dc.subjectB cellseng
dc.subjectCorticosteroidseng
dc.subjectMethotrexateeng
dc.subjectAutoimmunityeng
dc.titleAlterations on peripheral blood B-cell subpopulations in very early arthritis patientseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceOxfordpor
oaire.citation.endPage1092por
oaire.citation.startPage1082por
oaire.citation.titleRheumatologypor
person.familyNameCanhao
person.familyNameSilva Graca
person.familyNameFonseca
person.givenNameHelena
person.givenNameLuis Ricardo
person.givenNameJoão
person.identifierB-8887-2008
person.identifier.ciencia-id6C19-B162-F561
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0002-3239-2809
person.identifier.orcid0000-0001-6935-8500
person.identifier.orcid0000-0003-1432-3671
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id36138488700
person.identifier.scopus-author-id7101983519
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication48f3be39-37f9-44de-9c7e-22e49a89efe5
relation.isAuthorOfPublication9da841d6-508a-484b-a61e-ee2fab2bc226
relation.isAuthorOfPublication1772dc12-7c55-4c76-ae2d-c23270172480
relation.isAuthorOfPublication.latestForDiscovery9da841d6-508a-484b-a61e-ee2fab2bc226

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