Publication
Efficient thymopoiesis contributes to the maintenance of peripheral CD4 T cells during chronic human immunodeficiency virus type 2 infection
| dc.contributor.author | Gautier, D. | |
| dc.contributor.author | Beq, S. | |
| dc.contributor.author | Cortesão, C. S. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.contributor.author | Cheynier, R. | |
| dc.date.accessioned | 2015-09-22T10:01:43Z | |
| dc.date.available | 2015-09-22T10:01:43Z | |
| dc.date.issued | 2007 | |
| dc.description | © 2007, American Society for Microbiology. All Rights Reserved. | por |
| dc.description.abstract | Human immunodeficiency virus type 2 (HIV-2) infection leads to a lifelong asymptomatic period in the majority of patients. Even in patients with progressive disease, a slow CD4 count decline characterizes the chronic phase of HIV-2 infection, suggesting that peripheral T-cell homeostasis is controlled better following HIV-2 infection than following HIV-1 infection. Herein we showed that, in contrast to HIV-1-infected patients, HIV-2-infected patients demonstrate enhanced thymic function compared to age-matched healthy individuals. The correlation between higher thymic production and lower CD4 T-cell loss in these patients suggests that efficient thymopoiesis is implicated in the long-lasting maintenance of CD4 T-cell counts in HIV-2 disease. | por |
| dc.description.sponsorship | This work was supported by the Institut Pasteur and Fundação para a Ciência e Tecnologia (FCT) from Portugal (grant POCI/SAUMMO/60333 to A.E.S.). D.G. was the recipient of a Ph.D. ANRS scholarship, S.B. was the recipient of a SIDACTION postdoctoral grant, and C.S.C. received a Ph.D. scholarship from FCT. | por |
| dc.identifier.citation | Journal of Virology, Nov. 2007, Vol. 81, No. 22, p. 12685–12688 | por |
| dc.identifier.issn | 0022-538X | |
| dc.identifier.uri | http://dx.doi.org/10.1128/JVI.01131-07 | |
| dc.identifier.uri | http://hdl.handle.net/10451/20110 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | American Society for Microbiology | por |
| dc.title | Efficient thymopoiesis contributes to the maintenance of peripheral CD4 T cells during chronic human immunodeficiency virus type 2 infection | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/POCI/POCI%2FSAU-MMO%2F60333%2F2004/PT | |
| oaire.citation.title | Journal of Virology | por |
| oaire.fundingStream | POCI | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
| relation.isProjectOfPublication | 85b488bd-72f8-4ef4-99b0-aeefce9e6b59 | |
| relation.isProjectOfPublication.latestForDiscovery | 85b488bd-72f8-4ef4-99b0-aeefce9e6b59 |