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Prognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic review

2021Artigo científico Acesso aberto
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dc.contributor.authorRodrigues, Tiago
dc.contributor.authorRaposo, Sofia
dc.contributor.authorBrito, Dulce
dc.contributor.authorLopes, Luis
dc.date.accessioned2021-09-09T14:38:30Z
dc.date.available2021-09-09T14:38:30Z
dc.date.issued2021
dc.description© 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractBackground: Cardiopulmonary exercise test (CPET) is indicated as part of the assessment in hypertrophic cardiomyopathy (HCM) patients and stress echocardiography is often used to assess symptoms. However, the role of exercise testing for prognostic stratification in HCM is still not established. Aims: To systematically review the evidence on the role of exercise testing for prognostic stratification in hypertrophic cardiomyopathy. Methods: A systematic review was conducted for eligible publications, between 2010 and 2020, that included evaluation of outcomes and prognosis. In these studies, patients underwent exercise echocardiography and/or cardiopulmonary exercise testing, performed according to predefined protocols. Diverse parameters were assessed in order to determine which were relevant for the prognosis. Analyzed outcomes included death from any cause, sudden cardiac death (SCD) and equivalents, cardiovascular death, heart failure requiring hospitalization or progression to New York Heart Association classes III or IV, cardiac transplantation, non-sustained ventricular tachycardia, stroke, myocardial infarction and invasive septal reduction therapy. Results: Eighteen publications were included, corresponding to a total of 7525 patients. The mean follow-up period varied between 1 and 8 years. The main findings of these studies revealed that the major predictors of outcomes were abnormal heart rate recovery, abnormal blood pressure response exercise induced wall motion abnormalities, lower peak VO2, higher VE/VCO2, and pulmonary hypertension/exercise-induced pulmonary hypertension. Conclusion: Although most studies concluded that exercise test results are useful to determine prognosis in HCM, further investigation is needed regarding whether it adds independent value to the current risk stratification strategies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Cardiol. 2021 Sep 15;339:83-92pt_PT
dc.identifier.doi10.1016/j.ijcard.2021.06.051pt_PT
dc.identifier.eissn1874-1754
dc.identifier.issn0167-5273
dc.identifier.urihttp://hdl.handle.net/10451/49494
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/international-journal-of-cardiologypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectExercise testingpt_PT
dc.subjectHypertrophic cardiomyopathypt_PT
dc.subjectPrognostic stratificationpt_PT
dc.subjectSystematic reviewpt_PT
dc.titlePrognostic relevance of exercise testing in hypertrophic cardiomyopathy. A systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage92pt_PT
oaire.citation.startPage83pt_PT
oaire.citation.titleInternational Journal of Cardiologypt_PT
oaire.citation.volume339pt_PT
person.familyNameRodrigues
person.familyNameBrito
person.familyNameLopes
person.givenNameTiago
person.givenNameDulce
person.givenNameLuis
person.identifier1101129
person.identifier.ciencia-idF216-586F-1762
person.identifier.ciencia-idDB18-65D0-9683
person.identifier.orcid0000-0003-3248-1251
person.identifier.orcid0000-0003-1278-1847
person.identifier.orcid0000-0002-6408-4667
person.identifier.ridG-9650-2016
person.identifier.scopus-author-id7004510538
person.identifier.scopus-author-id9846194600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb74f4c16-d091-4895-90af-fa89e053642a
relation.isAuthorOfPublication196a2934-1434-433c-9735-81acb6fbe587
relation.isAuthorOfPublication9956d8c2-9780-4ff7-8d22-f581fbb96e42
relation.isAuthorOfPublication.latestForDiscovery196a2934-1434-433c-9735-81acb6fbe587

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