Repository logo
 
Publication

Serum levels of placental growth factor reflect the severity of retinopathy of prematurity

2021Journal article Restricted access
Simple item page
dc.contributor.authorAlmeida, Ana C.
dc.contributor.authorBitoque, Diogo B.
dc.contributor.authorMartins, Catarina
dc.contributor.authorCoelho, Constança
dc.contributor.authorBorrego, Luís Miguel
dc.contributor.authorSilva, Gabriela A.
dc.date.accessioned2021-10-01T10:24:51Z
dc.date.available2021-10-01T10:24:51Z
dc.date.issued2021
dc.description© 2021 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltdpt_PT
dc.description.abstractRetinopathy of prematurity (ROP) is a neovascular disorder of the immature retina and a leading cause of preventable blindness worldwide.1 A two-phase hypothesis for ROP pathogenesis has been suggested.1 Phase one is vaso-obliteration, where physiological vascularity is compromised and retinal vascular development is delayed by a hyperoxic environment. This induces vasoconstriction, with decreased levels of vascular endothelial growth factor (VEGF) and insulin growth factor-1. Phase two is vasoproliferation, where the avascular retina becomes hypoxic and releases angiogenic factors. This can lead to increased angiogenesis, with abnormal proliferation of the retinal vessels into the vitreous culminating in a retinal detachment.1 Placental growth factor (PGF) is a member of the VEGF family. Its precise contribution to ocular angiogenesis is not understood,2 but it may be important in ROP.pt_PT
dc.description.sponsorshipiNOVA4Health – UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia / Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is also acknowledged. The authors would also like to acknowledge Comprehensive Health Research Centre (CHRC) for their support in this study.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationActa Paediatr. 2021 Oct;110(10):2778-2779pt_PT
dc.identifier.doi10.1111/apa.15976pt_PT
dc.identifier.eissn1651-2227
dc.identifier.issn0803-5253
dc.identifier.urihttp://hdl.handle.net/10451/49768
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons, Inc.pt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/16512227pt_PT
dc.titleSerum levels of placental growth factor reflect the severity of retinopathy of prematuritypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04462%2F2013/PT
oaire.citation.endPage2779pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage2778pt_PT
oaire.citation.titleActa Paediatricapt_PT
oaire.citation.volume110pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication6e056d12-1fcb-4433-a629-00897ee10965
relation.isProjectOfPublication.latestForDiscovery6e056d12-1fcb-4433-a629-00897ee10965

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Serum_placental.pdf
Size:
289.3 KB
Format:
Adobe Portable Document Format
Download

Collections

FM-ISAMB-Artigos em Revistas Internacionais