Publication
Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections
| dc.contributor.author | Albuquerque, A. S. | |
| dc.contributor.author | Cortesão, C. S. | |
| dc.contributor.author | Foxall, R. B. | |
| dc.contributor.author | Victorino, R. M. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.date.accessioned | 2015-06-17T11:05:39Z | |
| dc.date.available | 2015-06-17T11:05:39Z | |
| dc.date.issued | 2007 | |
| dc.description | Copyright © 2007 by The American Association of Immunologists, Inc. | eng |
| dc.description.abstract | IL-7 is a nonredundant cytokine for T cell homeostasis. Circulating IL-7 levels increase in lymphopenic clinical settings, including HIV-1 infection. HIV-2 infection is considered a “natural” model of attenuated HIV disease given its much slower rate of CD4 decline than HIV-1 and limited impact on the survival of the majority of infected adults. We compared untreated HIV-1- and HIV-2-infected patients and found that the HIV-2 cohort demonstrated a delayed increase in IL-7 levels during the progressive depletion of circulating CD4 T cells as well as a dissociation between the acquisition of markers of T cell effector differentiation and the loss of IL-7Rα expression. This comparison of two persistent infections associated with progressive CD4 depletion and immune activation demonstrates that a better prognosis is not necessarily associated with higher levels of IL-7. Moreover, the delayed increase in IL-7 coupled with sustained expression of IL-7Rα suggests a maximization of available resources in HIV-2. The observation that increased IL-7 levels early in HIV-1 infection were unable to reduce the rate of CD4 loss and the impaired expression of the IL-7Rα irrespective of the state of cell differentiation raises concerns regarding the use of IL-7 therapy in HIV-1 infection. | eng |
| dc.description.sponsorship | This work was supported by a grant from Fundação para a Ciência e a Tecnologia and by Programa Operacional Ciência e Inovação 2010 Grant POCI2010 (to A.E.S.). A.S.A., C.S.C., R.B.F., and R.S.S. received scholarships from the Fundação para a Ciência e a Technologia. | eng |
| dc.identifier.citation | J Immunol 2007; 178:3252-3259 | por |
| dc.identifier.issn | 0022-1767 | |
| dc.identifier.uri | http://www.jimmunol.org/content/178/5/3252.long | |
| dc.identifier.uri | http://dx.doi.org/10.4049/jimmunol.178.5.3252 | |
| dc.identifier.uri | http://hdl.handle.net/10451/18296 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | American Association of Immunologists | eng |
| dc.relation.publisherversion | The definitive version is available at http://www.jimmunol.org/ | eng |
| dc.title | Rate of increase in circulating IL7 and loss of IL7Ralpha expression differ in HIV1 and HIV2 infections | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Journal of Immunology | eng |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |