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Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factor

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dc.contributor.authorRibeiro, Filipa
dc.contributor.authorFerreira, Filipa
dc.contributor.authorRodrigues, Rui S.
dc.contributor.authorSoares, Rita
dc.contributor.authorPedro, Diogo
dc.contributor.authorDuarte-Samartinho, Marta
dc.contributor.authorAroeira, Rita I.
dc.contributor.authorFerreiro, Elisabete
dc.contributor.authorValero, Jorge
dc.contributor.authorSolá, Susana
dc.contributor.authorMira, Helena
dc.contributor.authorSebastião, Ana M
dc.contributor.authorXapelli, Sara
dc.date.accessioned2023-09-28T16:28:51Z
dc.date.available2023-09-28T16:28:51Z
dc.date.issued2021
dc.description© 2021 AlphaMed Presspt_PT
dc.description.abstractAdenosine A2A receptor (A2A R) activation modulates several brain processes, ranging from neuronal maturation to synaptic plasticity. Most of these actions occur through the modulation of the actions of the neurotrophin brain-derived neurotrophic factor (BDNF). In this work, we studied the role of A2A Rs in regulating postnatal and adult neurogenesis in the rat hippocampal dentate gyrus (DG). Here, we show that A2A R activation with CGS 21680 promoted neural stem cell self-renewal, protected committed neuronal cells from cell death and contributed to a higher density of immature and mature neuronal cells, particularly glutamatergic neurons. Moreover, A2A R endogenous activation was found to be essential for BDNF-mediated increase in cell proliferation and neuronal differentiation. Our findings contribute to further understand the role of adenosinergic signaling in the brain and may have an impact in the development of strategies for brain repair under pathological conditions.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e a Tecnologia (FCT) (IF/01227/2015 granted to S. Xapelli) and COST Action BM14029. This project has received funding from H2020-WIDESPREAD-05-2020-Twinning (EpiEpinet) under grant agreement No. 952455. F.F.R. (SFRH/BD/74662/2010 and IMM/CT/35-2018), R.S. (SFRH/BD/128280/2017), and R.S.R. (SFRH/BD/129710/2017) were in receipt of a fellowship from FCT. E.F. is a holder of an investigator contract (CEECIND/00322/2017). We acknowledge support by the Spanish MICIU (SAF2015-70433-R), MICINN (PID2019-111225RB-I00), and PROMETEO/2018/055 from Generalitat Valenciana to H.M.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationStem Cells. 2021 Oct;39(10):1362-1381pt_PT
dc.identifier.doi10.1002/stem.3421pt_PT
dc.identifier.eissn1549-4918
dc.identifier.issn1066-5099
dc.identifier.urihttp://hdl.handle.net/10451/59503
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relationBM14029pt_PT
dc.relationH2020-WIDESPREAD-05-2020-Twinningpt_PT
dc.relationEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
dc.relationADENOSINE A2A RECEPTOR MODULATION OF NEURONAL MATURATION
dc.relationNot Available
dc.relation.publisherversionhttps://stemcellsjournals.onlinelibrary.wiley.com/journal/15494918pt_PT
dc.subjectNeural differentiationpt_PT
dc.subjectNeural stem cellspt_PT
dc.subjectNeuronpt_PT
dc.subjectProliferationpt_PT
dc.titleRegulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: Interaction with brain-derived neurotrophic factorpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
oaire.awardTitleADENOSINE A2A RECEPTOR MODULATION OF NEURONAL MATURATION
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01227%2F2015%2FCP1317%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/952455/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F74662%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00322%2F2017%2FCP1390%2FCT0001/PT
oaire.citation.endPage1381pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1362pt_PT
oaire.citation.titleStem Cellspt_PT
oaire.citation.volume39pt_PT
oaire.fundingStreamInvestigador FCT
oaire.fundingStreamH2020
oaire.fundingStreamCEEC IND 2017
person.familyNameRibeiro
person.familyNameRodrigues
person.familyNameSoares
person.familyNameFreire Leitão Duarte Mendes Pedro
person.familyNamePedro Aroeira
person.familyNameZeferino Solá da Cruz
person.familyNameSebastião
person.familyNameXapelli
person.givenNameFilipa
person.givenNameRui S
person.givenNameRita
person.givenNameDiogo Miguel
person.givenNameRita Isabel
person.givenNameSusana
person.givenNameAna M
person.givenNameSara
person.identifierM-5251-2013
person.identifier129383
person.identifier.ciencia-id6916-485D-36C3
person.identifier.ciencia-id6D10-6A4F-5B07
person.identifier.ciencia-id8B1F-4D7E-52CD
person.identifier.ciencia-id7E19-66A0-0A60
person.identifier.ciencia-id6E11-707D-B0DC
person.identifier.ciencia-idF112-55E8-E37E
person.identifier.ciencia-id7110-C8C3-ED42
person.identifier.orcid0000-0002-4006-7328
person.identifier.orcid0000-0002-9343-745X
person.identifier.orcid0000-0003-2072-0358
person.identifier.orcid0000-0002-4923-2940
person.identifier.orcid0000-0002-6886-3334
person.identifier.orcid0000-0003-2036-797X
person.identifier.orcid0000-0001-9030-6115
person.identifier.orcid0000-0001-6854-2509
person.identifier.ridS-1079-2018
person.identifier.scopus-author-id7004195841
person.identifier.scopus-author-id7004409879
person.identifier.scopus-author-id8721560200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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