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Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines

2007-07Journal article Open access
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dc.contributor.authorda Silva, Emilia Pereira
dc.contributor.authorMendes Pedro, Mónica
dc.contributor.authorVarela, Manuel Gato
dc.contributor.authorCortez-Dias, Nuno
dc.contributor.authorBicho, Manuel
dc.contributor.authorMadeira, Hugo
dc.contributor.authorLopes, Mario G.
dc.date.accessioned2021-05-14T15:36:25Z
dc.date.available2021-05-14T15:36:25Z
dc.date.issued2007-07
dc.descriptionCopyright © 2007 The Anatolian Journal of Cardiology.pt_PT
dc.description.abstractObjective: There is a well known association between mitral valve prolapse (MVP) and low blood pressure (BP), although patients often have high levels of catecholamines and high heart rate (HR). The main objective of our study was to evaluate the effects of long-term adrenergic beta-blockade on these parameters. Methods: The study population consisted of 46 patients with MVP and the control group consisted of 20 normal individuals. The study had two phases: in the first phase, patients were free of medications. In the second phase, patients were under treatment with propranolol for 10 to 12 months. The tests were performed in normal individuals and patients in the first phase. Only patients underwent the same tests in the second phase. Measurement of urinary epinephrine and norepinephrine levels, by high performance liquid chromatography, was done. Rest HR was determined by electrocardiogram (ECG), and ambulatory blood pressure and HR were evaluated by 24 hours ambulatory blood pressure monitoring (ABPM) using the auscultatory method. Results: The levels of epinephrine and norepinephrine were significantly higher in patients than in normal controls and decreased under propranolol. Rest and ambulatory HR were higher in patients and decreased under propranolol. The 24 hours systolic and diastolic BPs were lower in patients, and their values increased under propranolol. Heart rate decreasing and epinephrine levels reduction were positively correlated. No correlation was found between BP increase and catecholamine levels. Conclusion: The study results show divergent effects of propranolol on blood pressure, which increased, and on heart rate, that decreased, in patients with MVP. Heart rate decrease was an expected result and depends, namely, on b1 receptors blockade. Increase in BP is an unusual response to adrenergic beta-blockade in normal conditions, and this finding supports the preponderance of b2 receptors on the BP control in patients with MVP.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAnatol J Cardiol 2007: 7 Suppl 1; 107-109pt_PT
dc.identifier.eissn2149-2271
dc.identifier.issn2149-2263
dc.identifier.urihttp://hdl.handle.net/10451/47899
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAVES Yayıncılıkpt_PT
dc.relation.publisherversionhttps://anatoljcardiol.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectMitral valve prolapsept_PT
dc.subjectBlood pressurept_PT
dc.subjectHeart ratept_PT
dc.subjectBeta-blockadept_PT
dc.titleHeart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholaminespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage109pt_PT
oaire.citation.issueSuppl 1pt_PT
oaire.citation.startPage107pt_PT
oaire.citation.titleThe Anatolian Journal of Cardiologypt_PT
oaire.citation.volume7pt_PT
person.familyNameMendes Pedro
person.familyNameCortez-Dias
person.familyNameBicho
person.familyNameMadeira
person.familyNameLopes
person.givenNameMónica
person.givenNameNuno
person.givenNameManuel
person.givenNameHugo
person.givenNameMario G.
person.identifier.ciencia-id581D-B84F-DE80
person.identifier.ciencia-idD612-D3C3-6E1D
person.identifier.ciencia-id9512-8D22-1B28
person.identifier.ciencia-idAC1C-BBD0-2EDF
person.identifier.orcid0000-0002-2782-4398
person.identifier.orcid0000-0002-9244-4631
person.identifier.orcid0000-0002-5773-5687
person.identifier.orcid0000-0003-4291-2289
person.identifier.orcid0000-0002-2855-5118
person.identifier.scopus-author-id7004153755
person.identifier.scopus-author-id7004929005
person.identifier.scopus-author-id7202369014
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication36f4a32d-38e4-4c28-9140-4ba468059a22
relation.isAuthorOfPublicationc61e4f7e-28b3-47b4-bc5d-677b73fc3aec
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relation.isAuthorOfPublication.latestForDiscoveryc61e4f7e-28b3-47b4-bc5d-677b73fc3aec

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