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Growth differentiation factor 15 as a biomarker for risk stratification in the cardiothoracic surgery intensive care unit

2024Journal article Open access
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dc.contributor.authorFerreira, Ricardo
dc.contributor.authorVelho, Tiago R.
dc.contributor.authorPereira, Rafael Maniés
dc.contributor.authorPedroso, Dora
dc.contributor.authorDraiblate, Beatriz
dc.contributor.authorSantos, Susana Constantino Rosa
dc.contributor.authorNobre, Angelo
dc.contributor.authorAlmeida, Ana G.
dc.contributor.authorMoita, Luis
dc.contributor.authorPinto, Fausto J.
dc.date.accessioned2025-02-13T14:20:41Z
dc.date.available2025-02-13T14:20:41Z
dc.date.issued2024
dc.description© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractGrowth Differentiation Factor 15 (GDF15) is an emerging biomarker that significantly increases during acute stress responses, such as infections, and is moderately elevated in chronic and inflammation-driven conditions. While evidence suggests that high levels of GDF15 in cardiac surgery are associated with worse outcomes, its utility as an evaluator of early postoperative complications remains unclear. This study aims to characterize the postoperative profile of GDF15 in patients undergoing isolated surgical aortic valve replacement, evaluating its association with short-term outcomes. Serum samples from patients undergoing cardiac surgery were collected preoperatively and at defined postoperative time points (1 h, 6 h, 12 h, 24 h, and 48 h) to measure GDF15 levels. GDF15 levels significantly increased after surgery, peaking at 6 h. A positive correlation was observed between GDF15 levels and both cardiopulmonary bypass and aortic cross-clamp times. Notably, patients who developed postoperative acute kidney injury (AKI) or required prolonged hemodynamic support had significantly higher GDF15 levels, with increased mechanical ventilation time and extended intensive care unit length of stay. Furthermore, GDF15 levels correlated with postoperative SOFA scores at 24 h after surgery. GDF15 may be a valuable biomarker for risk stratification and guiding therapeutic decisions in cardiac surgery patients. Higher GDF15 levels were significantly associated with prolonged hemodynamic support, postoperative AKI, and measures of illness severity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiomolecules. 2024 Dec 13;14(12):1593pt_PT
dc.identifier.doi10.3390/biom14121593pt_PT
dc.identifier.eissn2218-273X
dc.identifier.urihttp://hdl.handle.net/10400.5/98404
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/biomoleculespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGDF15pt_PT
dc.subjectAcute kidney injurypt_PT
dc.subjectCardiac surgerypt_PT
dc.subjectCardiopulmonary bypasspt_PT
dc.subjectHemodynamic supportpt_PT
dc.subjectSurgical aortic valve replacementpt_PT
dc.titleGrowth differentiation factor 15 as a biomarker for risk stratification in the cardiothoracic surgery intensive care unitpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume14pt_PT
person.familyNameFerreira
person.familyNameVelho
person.familyNamePereira
person.familyNamePedroso
person.familyNameDraiblate
person.familyNameConstantino Rosa Santos
person.familyNameLucas Pereira Nobre
person.familyNameAlmeida
person.familyNameMoita
person.familyNamePinto
person.givenNameRicardo
person.givenNameTiago
person.givenNameRafael Maniés
person.givenNameDora
person.givenNameBeatriz
person.givenNameSusana
person.givenNameAngelo Manuel
person.givenNameAna Gomes de
person.givenNameLuis
person.givenNameFausto J.
person.identifier1814324
person.identifier335918
person.identifier1308889
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person.identifier.ciencia-id6D1C-B056-A429
person.identifier.ciencia-id3610-3184-3042
person.identifier.ciencia-idCA1C-AE28-33FE
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.orcid0000-0003-0084-3916
person.identifier.orcid0000-0002-0455-8189
person.identifier.orcid0000-0002-9604-1223
person.identifier.orcid0000-0002-5735-5094
person.identifier.orcid0000-0001-6315-5411
person.identifier.orcid0000-0002-5711-1292
person.identifier.orcid0000-0003-0360-4363
person.identifier.orcid0000-0003-0707-315X
person.identifier.orcid0000-0002-8034-4529
person.identifier.ridL-1296-2013
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id36667229700
person.identifier.scopus-author-id55628683100
person.identifier.scopus-author-id24554088300
person.identifier.scopus-author-id7102740158
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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