Publication
Gut disruption in HIV-2 infection despite reduced viremia
| dc.contributor.author | Fernandes, S. M. | |
| dc.contributor.author | Pires, A. R. | |
| dc.contributor.author | Ferreira, C. | |
| dc.contributor.author | Tendeiro, R. | |
| dc.contributor.author | Correia, L. | |
| dc.contributor.author | Paulo, S. E. | |
| dc.contributor.author | Victorino, R. M. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.date.accessioned | 2015-02-03T16:28:19Z | |
| dc.date.available | 2015-02-03T16:28:19Z | |
| dc.date.issued | 2014 | |
| dc.description | Copyright © Lippincott Williams & Wilkins. | por |
| dc.description.abstract | HIV-2 infection is highly prevalent inWest Africa and has been increasingly observed in non-African countries, mostly associated with migratory populations [1]. It has a much more benign course and lower viremia than HIV-1 [2], though with similar clinical spectra. Half of the HIV-2 infected patients with less than 200 CD4+ T-cells/ml exhibit undetectable viremia, despite harbouring numbers of infected cells comparable to their HIV-1 counterparts [3]. Moreover, CD4+ T-cell loss occurs in direct association with progressive immune activation in both infections, though the depletion rate is much slower in HIV-2 [2,4]. HIV-1 disease progression has been linked to disruption of gut-associated lymphoid tissue (GALT)and increased levels of microbial translocation, leading to systemic immune activation. There are currently no data on the impact of HIV-2 on GALT. Here, we provide evidence of HIV-2 replication in the gut despite the low viremia, which was associated with major mucosal disruption and CD4+ T-cell depletion that recovered upon antiretroviral treatment (ART). | por |
| dc.description.sponsorship | Thiswork was supported by the Fundação para a Ciência e Tecnologia (FCT), and the Programa Operacional Ciência e Inovação 2010 (PIC/IC/82712/2007 to A.E.S.). S.M.F., A.R.P. and R.T. received FCT scholarships. | por |
| dc.identifier.citation | AIDS 2014, Vol 28 No 2, p. 290-292 | por |
| dc.identifier.issn | 0269-9370 | |
| dc.identifier.uri | http://dx.doi.org/10.1097/QAD.0000000000000114 | |
| dc.identifier.uri | http://hdl.handle.net/10451/15876 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Lippincott, Williams & Wilkins | por |
| dc.relation.publisherversion | The definitive version is available at http://journals.lww.com/aidsonline/pages/default.aspx | por |
| dc.title | Gut disruption in HIV-2 infection despite reduced viremia | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | AIDS | por |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |