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Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence

2014Journal article Open access
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dc.contributor.authorMartins, João Martin
dc.contributor.authorVale, Sónia do
dc.contributor.authorMartins, Ana Filipa
dc.date.accessioned2020-12-09T14:20:54Z
dc.date.available2020-12-09T14:20:54Z
dc.date.issued2014
dc.descriptionCopyright © 2014 Joao Martin Martins et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractIntroduction. Adrenal glands play a major role in the control of blood pressure and mild defects of steroidogenesis and/or inappropriate control of mineralocorticoid production have been reported in high blood pressure (HBP). Patients and Methods. We used a specific protocol for the evaluation of 100 consecutive patients with inappropriate or recent onset HBP. Specific methods were used to confirm HBP and to diagnose secondary forms of HBP. In addition we tested adrenal steroidogenesis with the common cosyntropin test, modified to include the simultaneous measurement of renin and aldosterone besides 17-hydroxyprogesterone (17OHP) and 11-deoxycortisol (S). Results. Secondary forms of HBP were diagnosed in 32 patients, including 14 patients with primary hyperaldosteronism (PA) (14%) and 10 patients with pheochromocytoma (10%). Mild defects of the 21-hydroxylase (21OHD) and 11-hydroxylase (11OHD) enzymes were common (42%). ACTH-dependent aldosterone secretion was found in most patients (54%) and characteristically in those with mild defects of adrenal steroidogenesis (>60%), PA (>75%), and otherwise in patients with apparent essential HBP (EHBP) (32%). Discussion. Mild defects of adrenal steroidogenesis are common in patients with HBP, occurring in almost half of the patients. In those patients as well as in patients with apparent EHBP, aldosterone secretion is commonly dependent on ACTH.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Endocrinol. 2014;2014:295724.pt_PT
dc.identifier.doi10.1155/2014/295724pt_PT
dc.identifier.eissn1687-8345
dc.identifier.issn1687-8337
dc.identifier.urihttp://hdl.handle.net/10451/45188
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relation.publisherversionhttps://www.hindawi.com/journals/ije/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleMild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInternational Journal of Endocrinologypt_PT
oaire.citation.volume2014pt_PT
person.familyNameMartin Martins
person.familyNamedo Vale
person.familyNameMartins
person.givenNameJoão
person.givenNameSónia
person.givenNameAna Filipa
person.identifier282322
person.identifier.ciencia-id0E1A-AE02-05AB
person.identifier.orcid0000-0002-9545-9134
person.identifier.orcid0000-0001-9287-4095
person.identifier.orcid0000-0003-0730-4149
person.identifier.scopus-author-id15825086700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfbaa052e-a74c-4e7b-a25b-e548d7c7f366
relation.isAuthorOfPublicationcff86a29-07ce-4454-8325-5774370286ff
relation.isAuthorOfPublication51edb8f8-2064-4c66-b0c2-db2c01e42ce2
relation.isAuthorOfPublication.latestForDiscovery51edb8f8-2064-4c66-b0c2-db2c01e42ce2

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