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Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146

2021Artigo científico Acesso aberto
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dc.contributor.authorPereira da Silva, Tiago
dc.contributor.authorNapoleão, Patricia
dc.contributor.authorCosta, Marina C.
dc.contributor.authorGabriel, André F.
dc.contributor.authorSelas, Mafalda
dc.contributor.authorSilva, Filipa
dc.contributor.authorEnguita, Francisco J.
dc.contributor.authorFerreira, Rui Cruz
dc.contributor.authorCarmo, Miguel Mota
dc.date.accessioned2021-03-24T13:35:57Z
dc.date.available2021-03-24T13:35:57Z
dc.date.issued2021
dc.descriptionCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe mechanisms that regulate the systemic extent of atherosclerosis are not fully understood. We investigated whether the expression of circulating miRNAs is associated with the extent of stable atherosclerosis to a single territory or multiple territories (polyvascular) and with the severity of atherosclerosis in each territory. Ninety-four participants were prospectively recruited and divided into five age- and sex-matched groups: presenting no atherosclerosis, isolated coronary atherosclerosis, coronary and lower extremity atherosclerosis, coronary and carotid atherosclerosis, and atherosclerosis of the coronary, lower extremity, and carotid territories. The expression of six circulating miRNAs with distinct biological roles was assessed. The expression of miR-27b and miR-146 differed across groups (p < 0.05), showing a decrease in the presence of atherosclerosis, particularly in the three territories. miR-27b and miR-146 expression decreased in association with a higher severity of coronary, lower extremity, and carotid atherosclerosis. Polyvascular atherosclerosis involving the three territories was independently associated with a decreased miR-27b and miR-146 expression. Both miRNAs presented an area under the curve of ≥0.75 for predicting polyvascular atherosclerosis involving the three territories. To conclude, miR-27b and miR-146 were associated with the presence of severe polyvascular atherosclerosis and with the atherosclerosis severity in each territory. Both are potential biomarkers of severe systemic atherosclerosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDiagnostics (Basel). 2021 Feb 16;11(2):318.pt_PT
dc.identifier.doi10.3390/diagnostics11020318pt_PT
dc.identifier.eissn2075-4418
dc.identifier.urihttp://hdl.handle.net/10451/47015
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2075-4418/11/2/318pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAtherosclerosispt_PT
dc.subjectCarotid artery diseasept_PT
dc.subjectCoronary artery diseasept_PT
dc.subjectLower extremity arterial diseasept_PT
dc.subjectmiRNApt_PT
dc.subjectmiR-27bpt_PT
dc.subjectmiR-146pt_PT
dc.titleCirculating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.titleDiagnosticspt_PT
oaire.citation.volume11pt_PT
person.familyNameNapoleão
person.familyNameCosta
person.familyNameGabriel
person.familyNameEnguita
person.givenNamePatrícia
person.givenNameMarina
person.givenNameAndré Filipe Gonçalves
person.givenNameFrancisco J.
person.identifier887495
person.identifier173306
person.identifier.ciencia-idC11E-8BE9-A97F
person.identifier.ciencia-id6818-7810-6CEC
person.identifier.ciencia-id671C-AFF6-AF28
person.identifier.ciencia-idB215-8D49-3218
person.identifier.orcid0000-0002-5896-1440
person.identifier.orcid0000-0001-9020-7539
person.identifier.orcid0000-0002-6565-1600
person.identifier.orcid0000-0002-8072-8557
person.identifier.ridO-1710-2014
person.identifier.ridA-2347-2009
person.identifier.scopus-author-id8872775500
person.identifier.scopus-author-id55453276400
person.identifier.scopus-author-id57196534877
person.identifier.scopus-author-id6602119231
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc74643c7-434c-4310-9b98-2fcaa9fdd4b3
relation.isAuthorOfPublicationc4dcab9e-b873-4587-bb30-5203af150404
relation.isAuthorOfPublication41b20e24-4358-467c-a6d8-c7eb53d9ea87
relation.isAuthorOfPublicationa101dbd4-6bf5-4546-882e-e2596eddb6b4
relation.isAuthorOfPublication.latestForDiscoverya101dbd4-6bf5-4546-882e-e2596eddb6b4

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