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Role of tumor necrosis factor-α, interferon-γ and Fas-ligand on in vitro nitric oxide activity in the corpus luteum
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Orientador(es)
Resumo(s)
Normal reproductive function involves the expression of inflammatory mediators. Regarding the corpus luteum (CL), cytokines promote the cross-talk between immune, vascular and steroidogenic cells, among
others. Moreover, TNF, IFNG and FASL were shown to regulate equine CL establishment and regression.
We hypothesized that cytokines action on equine CL may be mediated by nitric oxide (NO), through the regulation of endothelial NO synthase (eNOS) expression. TNF increased eNOS mRNA level and NO metabolite (nitrite) production during CL growth. Cytokines combined action (TNF + IFNG + FASL) promoted
eNOS protein upregulation in mid-CL and nitrite production in mid and late-CL. However, in late-CL, TNF alone decreased nitrite secretion. These results indicate that in equine CL, cytokines TNF,
IFNG and FASL regulate NO activity, via eNOS expression modulation.
Descrição
Articles in International Journals
Palavras-chave
TNF-α IFN-γ Fas-ligand Nitric oxide Corpus luteum
Contexto Educativo
Citação
Galvão, A.M., Szóstek, A.Z., Skarzynski, D.J., & Ferreira-Dias, G.M. (2013). Role of tumor necrosis factor-x, interferon-y and Fas-ligand on in vitro nitric oxide activity in the corpus luteum. Cytokine, 64(1), 18–21. doi: 10.1016/j.cyto.2013.07.015
Editora
Elsevier Ltd.