Publication
Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation
| dc.contributor.author | Luis, Paula B. M. | |
| dc.contributor.author | Ruiter, Jos P. N. | |
| dc.contributor.author | Aires, Catia C. P. | |
| dc.contributor.author | Soveral, Graca | |
| dc.contributor.author | de Almelda, Isabel Tavares | |
| dc.contributor.author | Duran, Marinus | |
| dc.contributor.author | Wanders, Ronald J. A. | |
| dc.contributor.author | Silva, Margarida F. B. | |
| dc.date.accessioned | 2015-12-30T10:18:30Z | |
| dc.date.available | 2015-12-30T10:18:30Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | The effect of the antiepileptic drug valproic acid (VPA) on mitochondrial oxidative phosphorylation (OXPHOS) was investigated in vitro. Two experimental approaches were used, in the presence of selected respiratory-chain Substrates: (1) formation of ATP i | |
| dc.format | application/pdf | |
| dc.identifier.citation | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. - Vol. 1767, n. 9 (SEP 2007), p. 1126-1133 | |
| dc.identifier.doi | http://dx.doi.org/10.1016/j.bbabio.2007.06.007 | |
| dc.identifier.issn | 0005-2728 | |
| dc.identifier.uri | http://hdl.handle.net/10451/21625 | |
| dc.language.iso | eng | |
| dc.publisher | ELSEVIER SCIENCE BV | |
| dc.subject | Biochemistry & Molecular Biology | |
| dc.subject | Biophysics | |
| dc.title | Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1133 | por |
| oaire.citation.startPage | 1126 | por |
| oaire.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | por |
| oaire.citation.volume | Vol. 1767 | por |
| rcaap.rights | restrictedAccess | |
| rcaap.type | article |