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A pilot study on the efficacy of a single intra-articular administration of Triamcinolone Acetonide, Hyaluronan, and a combination of both for clinical management of osteoarthritis in Police Working Dogs

2020-11-06Journal article Open access
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dc.contributor.authorAlves, João C.
dc.contributor.authorSantos, Ana
dc.contributor.authorJorge, Patrícia
dc.contributor.authorLavrador, Catarina
dc.contributor.authorCarreira, L.Miguel
dc.date.accessioned2022-04-14T16:06:34Z
dc.date.available2022-04-14T16:06:34Z
dc.date.issued2020-11-06
dc.descriptionResearch Areas: Veterinary Sciencespt_PT
dc.description.abstractObjectives: To describe and compare the use and effectiveness of a single intra-articular injection (IA) of triamcinolone acetonide (TA), hyaluronan (HA), and a combination of both (TA+HA) in police working dogs with natural occurring hip osteoarthritis (OA). Study Design: Prospective, randomized, single-blinded study. Sample Population: Thirty animals with naturally occurring hip OA. Methods: Animals were randomly divided in three groups: GT, treated with 20 mg of TA per hip joint; GH, treated with treated 20 mg of HA per hip joint; and GTH, treated with a combination of 20 mg of TA and 20 mg of HA per hip joint. Response to treatment, measured by the Canine Brief Pain Inventory (divided in Pain Interference Score-PIS and Pain Severity Score-PSS) and the Hudson Visual Analog Scale (HVAS), was evaluated in seven different time points: T0 (before treatment), T1 (after 15 days), T2, T3, T4, T5, and T6 (after 1, 2, 3, 4, and 5 months, respectively). Results were compared using a Kruskal-Wallis test or a Wilcoxon signed ranks test, and p < 0.05 was set. Results: Comparing results of the different time points considered with T0, significant differences were registered in GH at T1 for HVAS (p = 0.03) and PIS (p = 0.04); and in GTH at T1 (p = 0.05 for HVAS and p < 0.05 for PIS), T2 (p < 0.04 for PIS), T3 (p < 0.03 for HVAS and p = 0.05 for PIS), T4 (p < 0.03 for HVAS and p < 0.05), and T5 (p < 0.05 for HVAS). No significant differences were found between groups when comparing scores in each time point. Individual treatment is considered successful with a reduction of >= 1 for PSS or >= 2 for PIS. In GTH, treatment was successful in four animals between T1 and T5 (40%, n = 10) and three at T6-T7 (30%, n = 10) for PSS and three animals of GTH at T1 (30%), two at T2 (20%), three between T3 and T4 (30%), and two between T5 and T7 (20%)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves JC, Santos A, Jorge P, Lavrador C, Carreira LM. 2020. A pilot study on the efficacy of a single intra-articular administration of Triamcinolone Acetonide, Hyaluronan, and a combination of both for clinical management of osteoarthritis in Police Working Dogs. Frontiers in Veterinary Science, 7:512523. DOI 10.3389/fvets.2020.512523pt_PT
dc.identifier.doi10.3389/fvets.2020.512523pt_PT
dc.identifier.eissn2297-1769
dc.identifier.urihttp://hdl.handle.net/10400.5/24080
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers, Media SApt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fvets.2020.512523/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimal modelpt_PT
dc.subjectOsteoarthritispt_PT
dc.subjectPainpt_PT
dc.subjectTriamcinolonept_PT
dc.subjectHyaluronanpt_PT
dc.subjectTriamcinolonept_PT
dc.subjectHyaluronanpt_PT
dc.titleA pilot study on the efficacy of a single intra-articular administration of Triamcinolone Acetonide, Hyaluronan, and a combination of both for clinical management of osteoarthritis in Police Working Dogspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.citation.conferencePlaceLausanne, Switzerlandpt_PT
oaire.citation.titleFrontiers in Veterinary Sciencept_PT
oaire.citation.volume7:512523pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCarreira
person.givenNameLuis Miguel
person.identifier.ciencia-idFD14-B321-EACD
person.identifier.orcid0000-0002-6784-2806
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3757a9f0-ab19-4225-bd5d-d68d19ec743a
relation.isAuthorOfPublication.latestForDiscovery3757a9f0-ab19-4225-bd5d-d68d19ec743a
relation.isProjectOfPublication8563a044-0c86-49a8-a275-8b1bb62cc0d8
relation.isProjectOfPublication.latestForDiscovery8563a044-0c86-49a8-a275-8b1bb62cc0d8

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