Repository logo
 
Publication

Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids

2021-11-29Journal article Open access
Simple item page
dc.contributor.authorDomingues, Célia P. F.
dc.contributor.authorRebelo, João S.
dc.contributor.authorMonteiro, Francisca
dc.contributor.authorNogueira, Teresa
dc.contributor.authorDionisio, Francisco
dc.date.accessioned2021-12-09T18:38:47Z
dc.date.available2021-12-09T18:38:47Z
dc.date.issued2021-11-29
dc.description.abstractConjugative plasmids are extrachromosomal mobile genetic elements pervasive among bacteria. Plasmids' acquisition often lowers cells' growth rate, so their ubiquity has been a matter of debate. Chromosomes occasionally mutate, rendering plasmids cost-free. However, these compensatory mutations typically take hundreds of generations to appear after plasmid arrival. By then, it could be too late to compete with fast-growing plasmid-free cells successfully. Moreover, arriving plasmids would have to wait hundreds of generations for compensatory mutations to appear in the chromosome of their new host. We hypothesize that plasmid-donor cells may use the plasmid as a ‘weapon’ to compete with plasmid-free cells, particularly in structured environments. Cells already adapted to plasmids may increase their inclusive fitness through plasmid transfer to impose a cost to nearby plasmid-free cells and increase the replication opportunities of nearby relatives. A mathematical model suggests conditions under which the proposed hypothesis works, and computer simulations tested the long-term plasmid maintenance. Our hypothesis explains the maintenance of conjugative plasmids not coding for beneficial genes. This article is part of the theme issue ‘The secret lives of microbial mobile genetic elements’.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1098/rstb.2020.0473pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/50321
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Royal Society Publishingpt_PT
dc.relationALG-01-0145-FEDER-028824pt_PT
dc.relationPTDC/BIAMIC/28824/2017pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectspiteful behaviour, social behaviour, structured habitat, compensatory mutations, inclusive fitness, conjugative plasmidspt_PT
dc.titleHarmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmidspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1842pt_PT
oaire.citation.titlePhilosophical Transactions of the Royal Society B: Biological Sciencespt_PT
oaire.citation.volume377pt_PT
person.familyNameDomingues
person.familyNameRebelo
person.familyNameSarreira Simões Horta Monteiro
person.familyNameVitorino Nogueira
person.familyNameDionísio
person.givenNameCélia
person.givenNameJoão
person.givenNameFrancisca
person.givenNameTeresa Isabel
person.givenNameFrancisco
person.identifierG-2273-2010
person.identifierA-2129-2009
person.identifier.ciencia-id3416-6299-1379
person.identifier.ciencia-idA015-FF75-397C
person.identifier.ciencia-idA815-CE3A-53C9
person.identifier.ciencia-idF211-4E18-2C69
person.identifier.ciencia-id7413-DB46-16E0
person.identifier.orcid0000-0003-2970-010X
person.identifier.orcid0000-0002-8662-7378
person.identifier.orcid0000-0002-5275-714X
person.identifier.orcid0000-0002-0059-5177
person.identifier.orcid0000-0002-3653-1511
person.identifier.scopus-author-id7004351448
person.identifier.scopus-author-id6506790127
rcaap.embargofctO formato aceite (não final) é autorizado pela revista para colocação em repositório publico sem tempo de embargo, já formato final requereria pagamento (APC)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4c8102d8-7751-4c14-9fde-9c61488e17b1
relation.isAuthorOfPublication09097aa0-9d09-459f-a089-84f103805fa4
relation.isAuthorOfPublication8063a7ff-bf07-4b7d-83a4-61786b528709
relation.isAuthorOfPublicationfd1c0a47-fb41-49e1-a4c9-2575917bc120
relation.isAuthorOfPublicationaa2a19c2-e8bf-4b68-98f3-737d4515e13e
relation.isAuthorOfPublication.latestForDiscoveryaa2a19c2-e8bf-4b68-98f3-737d4515e13e

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Domingues2021.pdf
Size:
1.94 MB
Format:
Adobe Portable Document Format
Download

Collections

cE3c - Artigos em Revistas Internacionais