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Publicação
The interaction of antibodies with lipid membranes unraveled by fluorescence methodologies
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Orientador(es)
Resumo(s)
The interest and investment in antibody therapies has reached an overwhelming scale in the last decade. Yet, little concern has been noticed among the scientific community to unravel important interactions of antibodies with biological structures other than their respective epitopes. Lipid membranes are particularly relevant in this regard as they set the stage for protein–protein recognition, a concept potentially inclusive of antibody–antigen recognition. Fluorescence techniques allow experimental monitoring of protein partition between aqueous and lipid phases, deciphering events of adsorption, insertion and diffusion. This review focuses on the available fluorescence spectroscopy methodologies directed to the study of antibody-membrane interactions
Descrição
© 2014 Elsevier B.V. All rights reserved.
Palavras-chave
Antibody Membrane Interaction Fluorescence Partition Lipid
Contexto Educativo
Citação
Journal of Molecular Structure 1077 (2014) 114–120
Editora
Elsevier