A carregar...
Publicação
Resistência na Tuberculose
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.98 MB | Adobe PDF |
Autores
Resumo(s)
O presente trabalho consiste no elemento de avaliação final do Mestrado em Análises
Clínicas, lecionado na Faculdade de Farmácia da Universidade de Lisboa.
A primeira parte integra o Relatório de Estágio que descreve o trabalho realizado durante o
estágio curricular no Laboratório de Patologia Clínica do Hospital da Luz, Grupo Synlab e no
Laboratório de Análises Clínicas Synlab, designado como laboratório central. Sob orientação
da Drª Isabel Moutinho, Especialista em Análises Clínicas, o estágio foi realizado nos
setores de Bioquímica, Hematologia, Microbiologia e Imunologia acompanhando todas as
fases do processo: pré-analítica, analítica e pós-analítica.
A segunda parte do trabalho inclui uma revisão de literatura atualizada sobre o tema
“Resistência na Tuberculose” cuja abordagem tem como base os mecanismos de
resistência aos fármacos de primeira e segunda linha, atualmente usados no tratamento da
tuberculose, e a referência aos novos fármacos e respetivas fases de estudo.
A tuberculose é uma doença infeciosa causada por micobactérias do complexo
Mycobacterium tuberculosis. A resistência aos fármacos usados no tratamento da
tuberculose tem aumentado significativamente, levando à necessidade de classificação da
tuberculose tendo em conta os fármacos aos quais a estirpe infetante é resistente.
Assim, concluímos que há uma enorme necessidade de investimento na investigação e
desenvolvimento de novos fármacos mas também de métodos que tornem mais rápido o
diagnóstico da infeção, reduzindo a probabilidade de aquisição de resistências.
The present document represents the element of final evaluation of a master's degree in clinical analyses, taught at the Faculty of Pharmacy of the University of Lisbon. The first part is part of the internship Report that describes the work carried out during the internship in the laboratory of clinical pathology at the Hospital da Luz, Synlab Group and Synlab Clinical analysis laboratory, designated as central laboratory. Under the guidance of Dr. Isabel Moutinho, specialist in clinical analyses, the training course was conducted in the fields of Biochemistry, hematology, microbiology and Immunology accompanied all the phases of the process: pre-analítical, analytical and post analytical stages. The second part of the work includes an updated literature review on the topic "resistance in Tuberculosis" which is based on the mechanisms of resistance to drugs of first and second line, currently used in the treatment of tuberculosis, and the reference to new drugs and respective stages of study. Tuberculosis is an infectious disease caused by Mycobacteria of the Mycobacterium tuberculosis complex. Resistance to drugs used in the treatment of tuberculosis has increased significantly, leading to the need for classification of tuberculosis in view of the drugs to which the infectious strain is resistant. Thus, we conclude that there is a huge need for investment in research and development of new drugs but also methods that make faster diagnosis of infection, reducing the likelihood of occurrence of new resistance acquisitions.
The present document represents the element of final evaluation of a master's degree in clinical analyses, taught at the Faculty of Pharmacy of the University of Lisbon. The first part is part of the internship Report that describes the work carried out during the internship in the laboratory of clinical pathology at the Hospital da Luz, Synlab Group and Synlab Clinical analysis laboratory, designated as central laboratory. Under the guidance of Dr. Isabel Moutinho, specialist in clinical analyses, the training course was conducted in the fields of Biochemistry, hematology, microbiology and Immunology accompanied all the phases of the process: pre-analítical, analytical and post analytical stages. The second part of the work includes an updated literature review on the topic "resistance in Tuberculosis" which is based on the mechanisms of resistance to drugs of first and second line, currently used in the treatment of tuberculosis, and the reference to new drugs and respective stages of study. Tuberculosis is an infectious disease caused by Mycobacteria of the Mycobacterium tuberculosis complex. Resistance to drugs used in the treatment of tuberculosis has increased significantly, leading to the need for classification of tuberculosis in view of the drugs to which the infectious strain is resistant. Thus, we conclude that there is a huge need for investment in research and development of new drugs but also methods that make faster diagnosis of infection, reducing the likelihood of occurrence of new resistance acquisitions.
Descrição
Tese de mestrado, Análises Clínicas, 2019, Universidade de Lisboa, Faculdade de Farmácia.
Palavras-chave
Mycobacterium tuberculosis Tuberculose Tratamento Resistência aos fármacos Novos fármacos. Teses de mestrado - 2019