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Neurologic manifestations of the antiphospholipid syndrome : an update

2021Artigo científico Acesso restrito
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dc.contributor.authorLeal Rato, Miguel
dc.contributor.authorBandeira, Matilde
dc.contributor.authorRomão, Vasco C.
dc.contributor.authorde Sousa, Diana Aguiar
dc.date.accessioned2021-06-16T13:45:13Z
dc.date.available2021-06-16T13:45:13Z
dc.date.issued2021
dc.description© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021pt_PT
dc.description.abstractPurpose of review: In recent years, the spectrum of neurological manifestations of antiphospholipid syndrome (APS) has been growing. We provide a critical review of the literature with special emphasis on presentation, proposed mechanisms of disease, and treatment of neurological involvement in APS. Recent findings: Although stroke is the most common cause of neurological manifestations in patients with APS, other neurological disorders have been increasingly associated with the disease, including cognitive dysfunction, headache, and epilepsy. Direct oral anticoagulants have failed to show non-inferiority compared to vitamin K antagonists for the prevention of major thrombotic events. Antiphospholipid antibodies are often found in patients with acute COVID-19 but clear evidence supporting an association between these antibodies and the risk of thrombotic events, including stroke and cerebral venous thrombosis, is still lacking. APS patients may present with several distinct neurological manifestations. New criteria will facilitate the classification of patients presenting with increasingly recognized non-criteria neurological manifestations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCurr Neurol Neurosci Rep. 2021 Jun 14;21(8):41pt_PT
dc.identifier.doi10.1007/s11910-021-01124-zpt_PT
dc.identifier.eissn1534-6293
dc.identifier.issn1528-4042
dc.identifier.urihttp://hdl.handle.net/10451/48592
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/11910pt_PT
dc.subjectAnticoagulationpt_PT
dc.subjectAntiphospholipidpt_PT
dc.subjectHeadachept_PT
dc.subjectStrokept_PT
dc.subjectThrombosispt_PT
dc.titleNeurologic manifestations of the antiphospholipid syndrome : an updatept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.titleCurrent Neurology and Neuroscience Reportspt_PT
oaire.citation.volume21pt_PT
person.familyNameLeal Rato
person.familyNameC Romão
person.familyNameAguiar de Sousa
person.givenNameMiguel
person.givenNameVasco
person.givenNameDiana
person.identifier661647
person.identifier490119
person.identifier574112
person.identifier.ciencia-idB812-C42E-B53B
person.identifier.ciencia-id771D-0A5C-626B
person.identifier.ciencia-id571C-121A-5CCB
person.identifier.orcid0000-0003-2233-0468
person.identifier.orcid0000-0002-5603-9436
person.identifier.orcid0000-0002-6702-7924
person.identifier.ridO-8224-2014
person.identifier.ridJ-4105-2013
person.identifier.scopus-author-id55989452300
person.identifier.scopus-author-id55781226000
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8161eead-031d-448a-8896-8dc88e5b9a34
relation.isAuthorOfPublicatione7e94139-add7-4a3b-b138-fb1d1a656b0e
relation.isAuthorOfPublication1d984575-dd95-4ca1-9092-bf6f9914ba63
relation.isAuthorOfPublication.latestForDiscovery1d984575-dd95-4ca1-9092-bf6f9914ba63

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