Repository logo
 
Publication

Adiponectin, Leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD

2021Journal article Unknown
Simple item page
dc.contributor.authorMarques, Vanda
dc.contributor.authorAfonso, Marta
dc.contributor.authorBierig, Nina
dc.contributor.authorDuarte-Ramos, Filipa
dc.contributor.authorSantos-Laso, Álvaro
dc.contributor.authorJimenez-Agüero, Raul
dc.contributor.authorEizaguirre, Emma
dc.contributor.authorBujanda, Luis
dc.contributor.authorPareja, Maria J.
dc.contributor.authorLuís, Rita
dc.contributor.authorCosta, Adília
dc.contributor.authorMachado, Mariana
dc.contributor.authorAlonso, Cristina
dc.contributor.authorArretxe, Enara
dc.contributor.authorAlustiza, José M.
dc.contributor.authorKrawczyk, Marcin
dc.contributor.authorLammert, Frank
dc.contributor.authorTiniakos, Dina G.
dc.contributor.authorFlehmig, Bertram
dc.contributor.authorCortez-Pinto, Helena
dc.contributor.authorBanales, Jesus M.
dc.contributor.authorCastro, Rui E.
dc.contributor.authorNormann, Andrea
dc.contributor.authorRodrigues, Cecília M. P.
dc.date.accessioned2023-03-03T17:01:17Z
dc.date.available2023-03-03T17:01:17Z
dc.date.issued2021
dc.descriptionCopyright © 2021 Marques, Afonso, Bierig, Duarte-Ramos, Santos-Laso, Jimenez-Agüero, Eizaguirre, Bujanda, Pareja, Luís, Costa, Machado, Alonso, Arretxe, Alustiza, Krawczyk, Lammert, Tiniakos, Flehmig, Cortez-Pinto, Banales, Castro, Normann and Rodrigues. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractBackground: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the metabolome. Materials and Methods: Leptin, adiponectin, and IGF-1 serum levels were measured by ELISA in two independent cohorts of biopsy-proven obese NAFLD patients and healthy-liver controls (discovery: 38 NAFLD, 13 controls; validation: 194 NAFLD, 31 controls) and correlated with clinical data, histology, genetic parameters, and serum metabolomics. Results: In both cohorts, leptin increased in NAFLD vs. controls (discovery: AUROC 0.88; validation: AUROC 0.83; p < 0.0001). The leptin levels were similar between obese and non-obese healthy controls, suggesting that obesity is not a confounding factor. In the discovery cohort, adiponectin was lower in non-alcoholic steatohepatitis (NASH) vs. non-alcoholic fatty liver (AUROC 0.87; p < 0.0001). For the validation cohort, significance was attained for homozygous for PNPLA3 allele c.444C (AUROC 0.63; p < 0.05). Combining adiponectin with specific serum lipids improved the assay performance (AUROC 0.80; p < 0.0001). For the validation cohort, IGF-1 was lower with advanced fibrosis (AUROC 0.67, p < 0.05), but combination with international normalized ratio (INR) and ferritin increased the assay performance (AUROC 0.81; p < 0.01). Conclusion: Serum leptin discriminates NAFLD, and adiponectin combined with specific lipids stratifies NASH. IGF-1, INR, and ferritin distinguish advanced fibrosis.pt_PT
dc.description.sponsorshipCR was funded by FEDER through the COMPETE program and by national funds through Fundação para a Ciência e a Tecnologia (PTDC/MED-FAR/29097/2017—LISBOA-01-0145-FEDER-029097) and by European Horizon 2020 (H2020-MSCA-RISE-2016-734719). This work was also supported by Fundação para a Ciência e Tecnologia (PD/BD/135467/2017) and Portuguese Association for the Study of Liver/MSD 2017. JB was funded by Spanish Carlos III Health Institute (ISCIII) (PI15/01132, PI18/01075 and Miguel Servet Program CON14/00129 and CPII19/00008), co-financed by Fondo Europeo de Desarrollo Regional (FEDER), Instituto de Salud Carlos III (CIBERehd, Spain), La Caixa Scientific Foundation (HR17-00601), Fundación Científica de la Asociación Española Contra el Cáncer, and European Horizon 2020 (ESCALON project: H2020-SC1-BHC-2018-2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Med (Lausanne). 2021 Jun 23;8:683250pt_PT
dc.identifier.doi10.3389/fmed.2021.683250pt_PT
dc.identifier.eissn2296-858X
dc.identifier.urihttp://hdl.handle.net/10451/56538
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationLISBOA-01-0145-FEDER-029097pt_PT
dc.relationH2020-MSCA-RISE-2016-734719pt_PT
dc.relationPD/BD/135467/2017pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/medicinept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIGF-1pt_PT
dc.subjectNAFLDpt_PT
dc.subjectAdiponectinpt_PT
dc.subjectCirculating biomarkerspt_PT
dc.subjectFibrosispt_PT
dc.subjectLeptinpt_PT
dc.subjectLipid metabolismpt_PT
dc.titleAdiponectin, Leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLDpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-FAR%2F29097%2F2017/PT
oaire.citation.titleFrontiers in Medicinept_PT
oaire.citation.volume8pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameda Silva Matos Serras Marques
person.familyNameBento Afonso
person.familyNameDuarte-Ramos
person.familyNameMachado
person.familyNameCortez-Pinto
person.familyNameCastro
person.familyNameRodrigues
person.givenNameVanda Isabel
person.givenNameMarta
person.givenNameFilipa
person.givenNameMariana
person.givenNameHelena
person.givenNameRui
person.givenNameCecilia
person.identifierB-9607-2019
person.identifier706834
person.identifier30919
person.identifier.ciencia-id4716-E0F9-1EC7
person.identifier.ciencia-id401C-8C11-1B93
person.identifier.ciencia-idF319-9233-8A55
person.identifier.ciencia-idA01C-0511-C986
person.identifier.ciencia-id3C1C-A6C2-71ED
person.identifier.ciencia-idDC18-39A7-F287
person.identifier.orcid0000-0003-3515-0781
person.identifier.orcid0000-0003-3011-4941
person.identifier.orcid0000-0001-6632-2553
person.identifier.orcid0000-0001-7769-7860
person.identifier.orcid0000-0002-8537-8744
person.identifier.orcid0000-0002-7417-0091
person.identifier.orcid0000-0002-4829-754X
person.identifier.ridP-5976-2016
person.identifier.ridI-2975-2013
person.identifier.ridM-3572-2013
person.identifier.scopus-author-id37059182200
person.identifier.scopus-author-id6507109091
person.identifier.scopus-author-id7202085681
person.identifier.scopus-author-id7202508239
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0afabc36-d20f-45d6-bc6a-38f001cb1734
relation.isAuthorOfPublication0d23231a-3271-4e0e-b9ab-2d1638acf429
relation.isAuthorOfPublication8ada3a03-35eb-4c9e-bdbf-3f879af1d77e
relation.isAuthorOfPublicationcfad9e93-f680-4e18-864f-b3954ee025ed
relation.isAuthorOfPublication91fdb4b3-d491-4e67-94ff-dcf5013fa1a7
relation.isAuthorOfPublicationfcf09dfd-d4a8-4818-840d-bc2f1ae2b690
relation.isAuthorOfPublicatione207ba8d-b67d-4f67-bbf4-d0858977a052
relation.isAuthorOfPublication.latestForDiscovery8ada3a03-35eb-4c9e-bdbf-3f879af1d77e
relation.isProjectOfPublication826ca5f9-f08f-438f-9763-7f8d34872646
relation.isProjectOfPublication.latestForDiscovery826ca5f9-f08f-438f-9763-7f8d34872646

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Adiponectin.pdf
Size:
1.85 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FM - Artigos em Revistas Internacionais