Repository logo
 
Publication

Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanoma

2021-03-30Journal article Open access
Simple item page
dc.contributor.authorLopes, Joana
dc.contributor.authorFerreira-Gonçalves, Tânia
dc.contributor.authorFigueiredo, Isabel V.
dc.contributor.authorRodrigues, Cecília M. P.
dc.contributor.authorFerreira, Hugo
dc.contributor.authorFerreira, David
dc.contributor.authorViana, Ana S.
dc.contributor.authorFaísca, Pedro
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorCoelho, João M. P.
dc.contributor.authorSilva, Catarina Oliveira
dc.contributor.authorReis, Catarina Pinto
dc.date.accessioned2022-04-12T11:04:18Z
dc.date.available2022-04-12T11:04:18Z
dc.date.issued2021-03-30
dc.date.updated2022-02-21T09:45:22Z
dc.descriptionSupplementary Materials - available online at https://www.mdpi.com/article/10.3390/biom11040511/s1pt_PT
dc.description.abstractThe global impact of cancer emphasizes the importance of developing innovative, effective and minimally invasive therapies. In the context of superficial cancers, the development of a multifunctional nanoparticle-based system and its in vitro and in vivo safety and efficacy characterization are, herein, proposed as a proof-of-concept. This multifunctional system consists of gold nanoparticles coated with hyaluronic and oleic acids, and functionalized with epidermal growth factor for greater specificity towards cutaneous melanoma cells. This nanoparticle system is activated by a near-infrared laser. The characterization of this nanoparticle system included several phases, with in vitro assays being firstly performed to assess the safety of gold nanoparticles without laser irradiation. Then, hairless immunocompromised mice were selected for a xenograft model upon inoculation of A375 human melanoma cells. Treatment with near-infrared laser irradiation for five minutes combined with in situ administration of the nanoparticles showed a tumor volume reduction of approximately 80% and, in some cases, led to the formation of several necrotic foci, observed histologically. No significant skin erythema at the irradiation zone was verified, nor other harmful effects on the excised organs. In conclusion, these assays suggest that this system is safe and shows promising results for the treatment of superficial melanoma.pt_PT
dc.description.sponsorshipThe authors would like to thank to Fundação para a Ciência e Tecnologia (FCT) for the essential financial support under the project’s references PTDC/BBB-BMC/0611/2012, UIDB/00645/2020, UIDB/04138/2020 and UIDP/04138/2020 as well as for the PhD fellowships SFRH/BD/148044/2019 and SFRH/BD/147306/2019.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLopes J, Ferreira-Gonçalves T, Figueiredo IV, Rodrigues CMP, Ferreira H, Ferreira D, et al. Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanoma. Biomolecules 2021;11(4):511. https://doi.org/10.3390/biom11040511pt_PT
dc.identifier.doihttps://doi.org/10.3390/biom11040511pt_PT
dc.identifier.eid2-s2.0-85103301695
dc.identifier.issn2218-273X
dc.identifier.slugcv-prod-2535156
dc.identifier.urihttp://hdl.handle.net/10451/52293
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPTDC/BBB-BMC/0611/2012pt_PT
dc.relationInstitute of <biophysics and Biomedical Engineering
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relationTargeting superficial tumors using a nanotechnological hybrid approach
dc.relationNon-invasive photoactivated nanodevices for mammary cancer treatment
dc.relation.publisherversionhttps://www.mdpi.com/2218-273X/11/4/511pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMultifunctional nanoparticlespt_PT
dc.subjectGold nanoparticlespt_PT
dc.subjectTargeted therapypt_PT
dc.subjectPhotothermal therapypt_PT
dc.subjectSuperficial tumorspt_PT
dc.subjectMelanomapt_PT
dc.subjectExperimental modelspt_PT
dc.titleProof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstitute of <biophysics and Biomedical Engineering
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleTargeting superficial tumors using a nanotechnological hybrid approach
oaire.awardTitleNon-invasive photoactivated nanodevices for mammary cancer treatment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00645%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F148044%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F147306%2F2019/PT
oaire.citation.issue4pt_PT
oaire.citation.startPage511pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
person.familyNameGonçalves
person.familyNameRodrigues
person.familyNamede Jesus Guilherme Gaspar
person.familyNameOliveira Silva
person.familyNameBeco Pinto Reis
person.givenNameTânia
person.givenNameCecilia
person.givenNameMaria Manuela
person.givenNameCatarina
person.givenNameAna Catarina
person.identifier30919
person.identifierC-2024-2014
person.identifierM-8132-2013
person.identifier.ciencia-id2914-A05C-F762
person.identifier.ciencia-idDC18-39A7-F287
person.identifier.ciencia-id3A10-0732-13F5
person.identifier.ciencia-id1317-A7D6-3B1C
person.identifier.orcid0000-0001-9916-3907
person.identifier.orcid0000-0002-4829-754X
person.identifier.orcid0000-0001-6814-7226
person.identifier.orcid0000-0002-5077-5176
person.identifier.orcid0000-0002-1046-4031
person.identifier.ridM-3572-2013
person.identifier.scopus-author-id57218871355
person.identifier.scopus-author-id7202508239
person.identifier.scopus-author-id15834627800
person.identifier.scopus-author-id14027161300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid2914-A05C-F762 | Tânia Sofia Ferreira Gonçalves
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf65c6fd6-44d0-44ed-9161-371024a59271
relation.isAuthorOfPublicatione207ba8d-b67d-4f67-bbf4-d0858977a052
relation.isAuthorOfPublication9e3a2d04-322f-4f0f-877c-45481624aa05
relation.isAuthorOfPublication815ae8b2-658b-4d1e-bce1-7e370d2ab033
relation.isAuthorOfPublication228cdf0e-ac72-4d38-bab4-b766e376becc
relation.isAuthorOfPublication.latestForDiscoveryf65c6fd6-44d0-44ed-9161-371024a59271
relation.isProjectOfPublication4d4fc9c0-9bf4-49e9-9635-bebd5edcb573
relation.isProjectOfPublicationbb00962c-ed82-4d7a-bc37-61df49767d93
relation.isProjectOfPublicationa21e6964-b01b-421e-9356-1ff6579cdd5c
relation.isProjectOfPublication030ec54d-d285-475c-b2ed-afa90d10cf9c
relation.isProjectOfPublication44247d7b-8b54-4fff-adcf-25213777ee08
relation.isProjectOfPublication.latestForDiscovery4d4fc9c0-9bf4-49e9-9635-bebd5edcb573

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Lopes2021.pdf
Size:
3.94 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FF - CiênciaVitae - Faculdade de Farmácia