Publicação
Dissecting striatal adenosine-cannabinoid receptor interactions. New clues from rats over-expressing adenosine A2A receptors
| dc.contributor.author | Ferré, Sergi | |
| dc.contributor.author | Sebastião, Ana M | |
| dc.date.accessioned | 2022-12-06T14:11:31Z | |
| dc.date.available | 2022-12-06T14:11:31Z | |
| dc.date.issued | 2016 | |
| dc.description | © 2016 International Society for Neurochemistry | pt_PT |
| dc.description.abstract | This Editorial highlights a study by Chiodi et al. () showing that the effects mediated by cannabinoid CB1 receptor (CB1R) activation in the striatum are significantly reduced in rats with neuronal over-expression of adenosine A2A receptors (A2AR). Two hypotheses are derived from that study. Hypothesis A: two subpopulations of pre-synaptic CB1R in corticostriatal glutamatergic terminals exist, one forming and another not forming heteromers with A2AR. Hypothesis B: CB1R are predominantly forming heteromers with A2AR. In the case of hypothesis A, the A2AR might be required for CB1R-A2AR heteromeric signaling, whereas non-heteromeric CB1R activity is inhibited by A2ARs. In the case of hypothesis B, up-regulation of A2ARs may perturb heteromeric stoichiometry, thus reducing CB1R functioning. In any case, pre-synaptic striatal A2AR-CB1R heteromers emerge as important targets of the effects of cannabinoids demonstrated at the neuronal and behavioral level. Read the highlighted article 'Striatal adenosine-cannabinoid receptor interactions in rats over-expressing adenosine A2A receptors' on page 907. | pt_PT |
| dc.description.sponsorship | This work was funded by the intramural funds of the National Institute on Drug Abuse (NIH, USA) and by Fundação para a Ciência e Tecnologia (FCT, Portugal). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | J. Neurochem. (2016) 136, 897-899 | pt_PT |
| dc.identifier.doi | 10.1111/jnc.13520 | pt_PT |
| dc.identifier.eissn | 1471-4159 | |
| dc.identifier.issn | 0022-3042 | |
| dc.identifier.uri | http://hdl.handle.net/10451/55354 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Wiley | pt_PT |
| dc.relation.publisherversion | https://onlinelibrary.wiley.com/journal/14714159 | pt_PT |
| dc.title | Dissecting striatal adenosine-cannabinoid receptor interactions. New clues from rats over-expressing adenosine A2A receptors | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 899 | pt_PT |
| oaire.citation.issue | 5 | pt_PT |
| oaire.citation.startPage | 897 | pt_PT |
| oaire.citation.title | Journal of Neurochemistry | pt_PT |
| oaire.citation.volume | 136 | pt_PT |
| person.familyName | Sebastião | |
| person.givenName | Ana M | |
| person.identifier.ciencia-id | F112-55E8-E37E | |
| person.identifier.orcid | 0000-0001-9030-6115 | |
| person.identifier.scopus-author-id | 7004409879 | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 304abd7f-071b-4447-a8a3-4aa5f0547141 | |
| relation.isAuthorOfPublication.latestForDiscovery | 304abd7f-071b-4447-a8a3-4aa5f0547141 |