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Safety and efficacy assessment of aerogels for biomedical applications

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dc.contributor.authorFerreira-Gonçalves, Tânia
dc.contributor.authorConstantin, Carolina
dc.contributor.authorNeagu, Monica
dc.contributor.authorReis, Catarina Pinto
dc.contributor.authorSabri, Firouzeh
dc.contributor.authorSimón-Vázquez, Rosana
dc.date.accessioned2022-04-11T17:43:55Z
dc.date.available2022-04-11T17:43:55Z
dc.date.issued2021
dc.date.updated2022-02-21T09:43:21Z
dc.description.abstractThe unique physicochemical properties of aerogels have made them an attractive class of materials for biomedical applications such as drug delivery, regenerative medicine, and wound healing. Their low density, high porosity, and ability to regulate the pore structure makes aerogels ideal nano/micro-structures for loading of drugs and active biomolecules. As a result of this, the number of in vitro and in vivo studies on the therapeutic efficacy of these porous materials has increased substantially in recent years and continues to be an area of great interest. However, data about their in vivo performance and safety is limited. Studies have shown that polymer-based, silica-based and some hybrid aerogels are generally regarded as safe but given that studies on the acute, subacute, and chronic toxicity for the majority of aerogel types is missing, more work is still needed. This review presents a comprehensive summary of different biomedical applications of aerogels proposed to date as well as new and innovative applications of aerogels in other areas such as decontamination. We have also reviewed their biological effect on cells and living organisms with a focus on therapeutic efficacy and overall safety (in vivo and in vitro).pt_PT
dc.description.sponsorshipWork carried out in the frame of the COST Action CA18125 “Advanced Engineering and Research of aeroGels for Environment and Life Sciences” (AERoGELS) and funded by the European Commission. The authors would like to thank to Fundação para a Ciência e Tecnologia (FCT) and Xunta de Galicia for funding for the support under the project’s references UIDB/04138/2020 and UIDP/04138/2020 as well as for the PhD fellowship SFRH/BD/147306/2019, and GRC-ED431C 2020/02.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira-Gonçalves T, Constantin C, Neagu M, Reis CP, Sabri F, Simón-Vázquez R. Safety and efficacy assessment of aerogels for biomedical applications. Biomedicine & Pharmacotherapy [Internet]. 2021;144:112356. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0753332221011409pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2021.112356pt_PT
dc.identifier.eid2-s2.0-85117722529
dc.identifier.issn19506007 07533322
dc.identifier.slugcv-prod-2679077
dc.identifier.urihttp://hdl.handle.net/10451/52287
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationGRC-ED431C 2020/02pt_PT
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relationNon-invasive photoactivated nanodevices for mammary cancer treatment
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0753332221011409?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectBiosensingpt_PT
dc.subjectTissue regenerationpt_PT
dc.subjectDrug deliverypt_PT
dc.subjectToxicitypt_PT
dc.subjectWound healingpt_PT
dc.titleSafety and efficacy assessment of aerogels for biomedical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleNon-invasive photoactivated nanodevices for mammary cancer treatment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F147306%2F2019/PT
oaire.citation.startPage112356pt_PT
oaire.citation.titleBiomedicine and Pharmacotherapypt_PT
oaire.citation.volume144pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
person.familyNameGonçalves
person.familyNameBeco Pinto Reis
person.givenNameTânia
person.givenNameAna Catarina
person.identifierM-8132-2013
person.identifier.ciencia-id2914-A05C-F762
person.identifier.ciencia-id1317-A7D6-3B1C
person.identifier.orcid0000-0001-9916-3907
person.identifier.orcid0000-0002-1046-4031
person.identifier.scopus-author-id57218871355
person.identifier.scopus-author-id14027161300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid2914-A05C-F762 | Tânia Sofia Ferreira Gonçalves
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf65c6fd6-44d0-44ed-9161-371024a59271
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