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Trypanosoma brucei parasites occupy and functionally adapt to the adipose tissue in mice

2016Journal article Open access
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dc.contributor.authorTrindade, Sandra
dc.contributor.authorRijo-Ferreira, Filipa
dc.contributor.authorCarvalho, Tânia
dc.contributor.authorNeves, Daniel
dc.contributor.authorGuegan, Fabien Marc
dc.contributor.authorAresta-Branco, Francisco
dc.contributor.authorBento, Fabio
dc.contributor.authorYoung, Simon A.
dc.contributor.authorPinto, Andreia
dc.contributor.authorVan Den Abbeele, Jan
dc.contributor.authorRibeiro, Ruy M.
dc.contributor.authorDias, Sérgio
dc.contributor.authorSmith, Terry K.
dc.contributor.authorFigueiredo, Luisa M.
dc.date.accessioned2020-12-03T18:34:12Z
dc.date.available2020-12-03T18:34:12Z
dc.date.issued2016
dc.description© 2016 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)pt_PT
dc.description.abstractTrypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, trypanosomes are thought to exist in two major niches: early in infection, they populate the blood; later, they breach the blood-brain barrier. Working with a well-established mouse model, we discovered that adipose tissue constitutes a third major reservoir for T. brucei. Parasites from adipose tissue, here termed adipose tissue forms (ATFs), can replicate and were capable of infecting a naive animal. ATFs were transcriptionally distinct from bloodstream forms, and the genes upregulated included putative fatty acid β-oxidation enzymes. Consistent with this, ATFs were able to utilize exogenous myristate and form β-oxidation intermediates, suggesting that ATF parasites can use fatty acids as an external carbon source. These findings identify the adipose tissue as a niche for T. brucei during its mammalian life cycle and could potentially explain the weight loss associated with sleeping sickness.pt_PT
dc.description.sponsorshipThis work was supported by 55007419 (HHMI) and 2151 (EMBO) to L.M.F., D.P.-N., F.B., and F.G.; FCT fellowships to S.T., F.R.-F., and F.A.-B. (SFRH/BPD/ 89833/2012, SFRH/BD/51286/2010, and SFRH/BD/80718/2011, respectively); Wellcome Trust grant (093228), MRC MR/M020118/1, and European Community Seventh Framework Programme under grant agreement No. 602773 (Project KINDRED) to S.A.Y. and T.K.S.; and PAI 7/41 (Belspo) and ERC-NANOSYM to J.V.D.A.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCell Host Microbe. 2016 Jun 8; 19 (6): 837-48pt_PT
dc.identifier.doi10.1016/j.chom.2016.05.002pt_PT
dc.identifier.eissn1934-6069
dc.identifier.issn1931-3128
dc.identifier.urihttp://hdl.handle.net/10451/45123
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMRC MR/M020118/1pt_PT
dc.relationNot available
dc.relationA FORWARD GENETICS APPROACH TO IDENTIFY REGULATORS OF ANTIGENIC VARIATION IN TRYPANOSOMA BRUCEI
dc.relationKinetoplastid Drug Development: strengthening the preclinical pipeline
dc.relationInvestigating Trypanosoma brucei's unusual inositol metabolism.
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/cell-host-and-microbept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAfrican trypanosomespt_PT
dc.subjectFatpt_PT
dc.subjectFatty acid β-oxidationpt_PT
dc.subjectMetabolismpt_PT
dc.subjectMouse infectionpt_PT
dc.subjectTranscriptomept_PT
dc.titleTrypanosoma brucei parasites occupy and functionally adapt to the adipose tissue in micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot available
oaire.awardTitleA FORWARD GENETICS APPROACH TO IDENTIFY REGULATORS OF ANTIGENIC VARIATION IN TRYPANOSOMA BRUCEI
oaire.awardTitleKinetoplastid Drug Development: strengthening the preclinical pipeline
oaire.awardTitleInvestigating Trypanosoma brucei's unusual inositol metabolism.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F89833%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F51286%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F80718%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/602773/EU
oaire.awardURIinfo:eu-repo/grantAgreement/WT/Immune System in Health and Disease/093228
oaire.citation.endPage848pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage837pt_PT
oaire.citation.titleCell Host & Microbept_PT
oaire.citation.volume19pt_PT
oaire.fundingStreamOE
oaire.fundingStreamSFRH
oaire.fundingStreamFP7
oaire.fundingStreamImmune System in Health and Disease
person.familyNameTrindade
person.familyNameRijo-Ferreira
person.familyNameCarvalho
person.familyNameNeves
person.familyNameGuegan
person.familyNamePinto
person.familyNameRibeiro
person.familyNameDias
person.familyNameFigueiredo
person.givenNameSandra
person.givenNameFilipa
person.givenNameTânia
person.givenNameDaniel
person.givenNameFabien Marc
person.givenNameAndreia
person.givenNameRuy Miguel
person.givenNameSérgio
person.givenNameLuisa M
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameWellcome Trust
rcaap.rightsopenAccesspt_PT
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