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Hypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysis

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dc.contributor.authorCardoso, Ana
dc.contributor.authorBranco, Carolina
dc.contributor.authorSant’Ana, Mariana
dc.contributor.authorCosta, Cláudia
dc.contributor.authorMarques Da Silva, Bernardo
dc.contributor.authorAgapito Fonseca, José
dc.contributor.authorOuterelo, Cristina
dc.contributor.authorGameiro, Joana
dc.date.accessioned2023-10-16T14:07:47Z
dc.date.available2023-10-16T14:07:47Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractIntroduction: The prevalence of chronic kidney disease (CKD) and heart failure (HF) has been rising over the past decade, with a prevalence close to 40%. Cardiovascular disease and malnutrition are common comorbidities and known risk factors for mortality in haemodialysis (HD) patients. We aimed to evaluate the one-year mortality rate after dialysis induction, and the impact of serum albumin levels on survival outcomes, in patients with CKD and HF. Methods: This was a retrospective analysis of patients with CKD and HF who underwent chronic HD between January 2016 and December 2019 in a tertiary-care Portuguese hospital. Variables were submitted to univariate and multivariate analysis to determine factors predictive of one-mortality after HD start. Results: In total, 204 patients were analysed (mean age 75.1 ± 10.3 years). Within the first year of HD start, 28.7% of patients died. These patients were significantly older [79.8 ± 7.2 versus 72.9 ± 10.9 years, p < 0.001; OR 1.08 (1.04-1.13), p < 0.001] and had a higher mean Charlson Index [9.0 ± 1.8 versus 8.3 ± 2.0, p = 0.015; OR 1.22 (1.04-1.44), p = 0.017], lower serum creatinine [5.1 ± 1.6 mg/dL versus 5.8 ± 2.0 mg/dL; p = 0.021; OR 0.80 (0.65-0.97), p = 0.022], lower albumin levels [3.1 ± 0.6 g/dL versus 3.4 ± 0.6 g/dL, p < 0.001; OR 0.38 (0.22-0.66), p = 0.001] and started haemodialysis with a central venous catheter more frequently [80.4% versus 66.2%, p = 0.050]. Multivariate analysis identified older age [aOR 1.07 (1.03-1.12), p = 0.002], lower serum creatinine [aOR 0.80 (0.64-0.99), p = 0.049] and lower serum albumin [aOR 0.41 (0.22-0.75), p = 0.004] as predictors of one-year mortality. Conclusion: In our cohort, older age, lower serum creatinine and lower serum albumin were independent risk factors for one-year mortality, highlighting the prognostic importance of malnutrition in patients starting chronic HD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Clin Med. 2021 Sep 29;10(19):4518.pt_PT
dc.identifier.doi10.3390/jcm10194518pt_PT
dc.identifier.eissn2077-0383
dc.identifier.urihttp://hdl.handle.net/10451/59788
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/jcmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChronic haemodialysispt_PT
dc.subjectHeart failurept_PT
dc.subjectHypoalbuminaemiapt_PT
dc.subjectMalnutritionpt_PT
dc.subjectMortalitypt_PT
dc.titleHypoalbuminaemia and one-year mortality in haemodialysis patients with heart failure: a cohort analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue19pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume10pt_PT
person.familyNameCardoso
person.familyNameBranco
person.familyNameCosta
person.familyNameMarques da Silva
person.familyNameAgapito Fonseca
person.familyNameGameiro
person.givenNameAna
person.givenNameCarolina
person.givenNameCláudia
person.givenNameBernardo
person.givenNameJosé
person.givenNameJoana
person.identifier2253753
person.identifier.ciencia-idA314-3F04-FB6A
person.identifier.orcid0000-0002-1268-8768
person.identifier.orcid0000-0002-3073-0253
person.identifier.orcid0000-0002-6468-1306
person.identifier.orcid0000-0003-0665-4446
person.identifier.orcid0000-0001-7675-216X
person.identifier.orcid0000-0001-6143-461X
person.identifier.scopus-author-id57188862430
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2f317fdc-344e-473c-9a15-b869b2e838fe
relation.isAuthorOfPublicationc2f5edf7-1d1c-483d-8939-0094caad5857
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relation.isAuthorOfPublication.latestForDiscovery170e3e95-60d7-48ad-9f61-eb255c9bea0a

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