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Denmark14-230 clone as an increasing cause of peumococcal infection in Portugal within a background of diverse serotype 19A lineages
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Orientador(es)
Resumo(s)
Pneumococci of serotype 19A are increasingly found to be the cause of infection in various geographic
regions. We have characterized the serotype 19A isolates (n = 288) found among pneumococci responsible for
infections (n = 1,925) and pneumococci recovered from asymptomatic carriers (n = 1,973) in Portugal between
2001 and 2006. We show that despite the existence of serotype 19A clones that have a greater potential to cause
invasive disease or an enhanced colonization capacity, the lineage that is increasing as a cause of infection in
Portugal is a multiresistant clone that is competent at both. The expanding Denmark14-230 clone found in
Portugal is disseminated in other Mediterranean countries, where it is also increasingly responsible for
invasive infections in both children and adults. The lineages driving the rise of serotype 19A infections in Asia
and the United States (sequence type 320 [ST320] and ST199) are either absent or account for only a small
proportion of isolates in Portugal. These data highlight the importance of locally circulating clones with the
ability to compete in the nasopharyngeal niche in the emergence of the serotype 19A lineages which are an
increasing cause of infection in various geographic regions.
Descrição
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Palavras-chave
Denmark14-230 clone Pneumococcal Infection Serotype 19A Portugal
Contexto Educativo
Citação
JOURNAL OF CLINICAL MICROBIOLOGY, Jan. 2010, p. 101–108