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A Preliminary Report on the Combined Effect of Intra-Articular Platelet-Rich Plasma Injections and Photobiomodulation in Canine Osteoarthritis

2023-10-18Journal article Open access
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dc.contributor.authorAlves, J.C.
dc.contributor.authorSantos, Ana
dc.contributor.authorCarreira, L.Miguel
dc.date.accessioned2024-06-29T19:49:32Z
dc.date.available2024-06-29T19:49:32Z
dc.date.issued2023-10-18
dc.descriptionResearch Areas: AgricultureVeterinary; Sciences; Zoologypt_PT
dc.description.abstractOsteoarthritis (OA) is highly prevalent in the canine population. Due to the multiple dimensions of the disease, a multimodal approach is usually favored by clinicians. To evaluate the combined treatment with intra-articular platelet-rich plasma (PRP) and photobiomodulation in dogs with bilateral hip OA, thirty dogs were assigned to a PRP group (PRPG, n = 10), a photobiomodulation group (PBMTG, n = 10), or a combined therapies group (PRP+PBMTG, n = 10). The PRPG received two intra-articular administrations of platelet-rich plasma 14 days apart. The PBMTG received photobiomodulation with a therapeutic laser, with three sessions every other day in week one; two sessions in week two; a single session in week three; and one session/month on follow-up evaluation days. The PRP+PBMTG received the two combined therapies. The response to treatment was evaluated with weight-bearing distribution and the Canine Brief Pain Inventory, the Liverpool Osteoarthritis in Dogs, and the Canine Orthopedic Index. Evaluations were conducted before treatment and +8, +15, +30, +60, and +90 days after initial treatment. Normality was assessed with a Shapiro–Wilk test, and the groups’ results in each evaluation moment were compared using a Mann–Whitney U test. Animals of both sexes (male n = 19, female n = 11) were included in the sample, with a mean age of 7.8 ± 2.5 years and a body weight of 26.5 ± 4.7 kg. Joints were classified as mild (n = 6, three in PRPG, two in PBMTG, and one in PRP+PBMTG), moderate (n = 18, six in PRPG, five in PBMTG, and seven in PRP+PBMTG), and severe (n = 6, one in PRPG, three in PBMTG, and two in PRP+PBMTG). No differences were found between groups at the initial evaluation. All treatments produced clinically significant improvements compared to the assessment on treatment day. The combination of PRP and photobiomodulation produced greater, longer-lasting improvements. PRP and photobiomodulation can improve objective outcomes and client-reported outcome measures in dogs with OA. Their combined use leads to greater, longer-lasting, clinically significant improvementspt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves JC, Santos A, Carreira LM. 2023. A Preliminary Report on the Combined Effect of Intra-Articular Platelet-Rich Plasma Injections and Photobiomodulation in Canine Osteoarthritis. Animals, 13(20):3247. doi:10.3390/ani13203247pt_PT
dc.identifier.doi10.3390/ani13203247pt_PT
dc.identifier.issn2076-2615
dc.identifier.urihttp://hdl.handle.net/10400.5/31198
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-2615/13/20/3247pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDogpt_PT
dc.subjectOsteoarthritispt_PT
dc.subjectChronic painpt_PT
dc.subjectOrthopedicspt_PT
dc.subjectPlatelet-rich plasmapt_PT
dc.subjectRegenerative therapypt_PT
dc.subjectPhotobiomodulationpt_PT
dc.titleA Preliminary Report on the Combined Effect of Intra-Articular Platelet-Rich Plasma Injections and Photobiomodulation in Canine Osteoarthritispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.issue3247pt_PT
oaire.citation.titleAnimalspt_PT
oaire.citation.volume13(20)pt_PT
person.familyNameCarreira
person.givenNameLuis Miguel
person.identifier.ciencia-idFD14-B321-EACD
person.identifier.orcid0000-0002-6784-2806
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3757a9f0-ab19-4225-bd5d-d68d19ec743a
relation.isAuthorOfPublication.latestForDiscovery3757a9f0-ab19-4225-bd5d-d68d19ec743a

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