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The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment

2022-01-04Journal article Open access
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dc.contributor.authorFerreira-Gonçalves, Tânia
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorCoelho, João M. P.
dc.contributor.authorMarques, Vanda
dc.contributor.authorViana, Ana S.
dc.contributor.authorAscensão, Lia
dc.contributor.authorCarvalho, Lina
dc.contributor.authorRodrigues, Cecília M. P.
dc.contributor.authorFerreira, Hugo Alexandre
dc.contributor.authorFerreira, David
dc.contributor.authorReis, Catarina Pinto
dc.date.accessioned2022-04-12T12:07:19Z
dc.date.available2022-04-12T12:07:19Z
dc.date.issued2022-01-04
dc.date.updated2022-02-21T09:52:59Z
dc.description.abstractBreast cancer is a high-burden malignancy for society, whose impact boosts a continuous search for novel diagnostic and therapeutic tools. Among the recent therapeutic approaches, photothermal therapy (PTT), which causes tumor cell death by hyperthermia after being irradiated with a light source, represents a high-potential strategy. Furthermore, the effectiveness of PTT can be improved by combining near infrared (NIR) irradiation with gold nanoparticles (AuNPs) as photothermal enhancers. Herein, an alternative synthetic method using rosmarinic acid (RA) for synthesizing AuNPs is reported. The RA concentration was varied and its impact on the AuNPs physicochemical and optical features was assessed. Results showed that RA concentration plays an active role on AuNPs features, allowing the optimization of mean size and maximum absorbance peak. Moreover, the synthetic method explored here allowed us to obtain negatively charged AuNPs with sizes favoring the local particle accumulation at tumor site and maximum absorbance peaks within the NIR region. In addition, AuNPs were safe both in vitro and in vivo. In conclusion, the synthesized AuNPs present favorable properties to be applied as part of a PTT system combining AuNPs with a NIR laser for the treatment of breast cancer.pt_PT
dc.description.sponsorshipThe authors would like to thank to Fundação para a Ciência e a Tecnologia (FCT) for the essential financial support under project references UIDB/00645/2020, UIDB/04138/2020, UIDP/04138/2020 and UIDB/00100/2020. Authors are also thankful for the financial support given to CESAM through national funds by FCT/MCTES under project references UIDP/50017/2020 and UIDB/50017/2020, and through co-funding by FEDER within the PT2020 Partnership Agreement and Compete 2020. Moreover, T.F.-G. would like to thank FCT for the PhD Fellowship SFRH/BD/147306/2019.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira-Gonçalves T, Gaspar MM, Coelho JMP, Marques V, Viana AS, Ascensão L, et al. The role of rosmarinic acid on the bioproduction of gold nanoparticles as part of a photothermal approach for breast cancer treatment. Biomolecules [Internet]. 2022;12(1):71. Disponível em: https://www.mdpi.com/2218-273X/12/1/71pt_PT
dc.identifier.doihttps://doi.org/10.3390/biom12010071pt_PT
dc.identifier.issn2218-273X
dc.identifier.slugcv-prod-2679076
dc.identifier.urihttp://hdl.handle.net/10451/52297
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationInstitute of <biophysics and Biomedical Engineering
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relationCentro de Química Estrutural
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relationNon-invasive photoactivated nanodevices for mammary cancer treatment
dc.relation.publisherversionhttps://www.mdpi.com/2218-273X/12/1/71pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectrosmarinic acidpt_PT
dc.subjectgold nanoparticlespt_PT
dc.subjectphotothermal therapypt_PT
dc.subjectbreast cancer treatmentpt_PT
dc.titleThe Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstitute of <biophysics and Biomedical Engineering
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleNon-invasive photoactivated nanodevices for mammary cancer treatment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00645%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F147306%2F2019/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage71pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume12pt_PT
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person.familyNameGonçalves
person.familyNamede Jesus Guilherme Gaspar
person.familyNameRodrigues
person.familyNameBeco Pinto Reis
person.givenNameTânia
person.givenNameMaria Manuela
person.givenNameCecilia
person.givenNameAna Catarina
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person.identifier.ridM-3572-2013
person.identifier.scopus-author-id57218871355
person.identifier.scopus-author-id15834627800
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person.identifier.scopus-author-id14027161300
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid2914-A05C-F762 | Tânia Sofia Ferreira Gonçalves
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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