Repository logo
 
Publication

Thrombocytopenia is associated with an increased risk of cancer during treated HIV disease

2014Journal article Restricted access
Simple item page
dc.contributor.authorBorges, Álvaro H.
dc.contributor.authorLundgren, Jens D.
dc.contributor.authorRidolfo, Annalisa
dc.contributor.authorKatlama, Christine
dc.contributor.authorAntunes, Francisco
dc.contributor.authorGrzeszczuk, Anna
dc.contributor.authorBlaxhult, Anders
dc.contributor.authorMitsura, Viktar M.
dc.contributor.authorDoroana, Manuela
dc.contributor.authorBattegay, Manuel
dc.contributor.authorGargalianos, Panagiotis
dc.contributor.authorMocroft, Amanda
dc.date.accessioned2022-02-15T14:56:42Z
dc.date.available2022-02-15T14:56:42Z
dc.date.issued2014
dc.descriptionCopyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkinspt_PT
dc.description.abstractObjective: To assess the relationship between platelet counts and risk of AIDS and non-AIDS-defining events. Design: Prospective cohort. Methods: EuroSIDA patients with at least one platelet count were followed from baseline (first platelet ≥ 1 January 2005) until last visit or death. Multivariate Poisson regression was used to assess the relationship between current platelet counts and the incidence of non-AIDS-defining (pancreatitis, end-stage liver/renal disease, cancer, cardiovascular disease) and AIDS-defining events. Results: There were 62 898 person-years of follow-up (PYFU) among 12 279 patients, including 1168 non-AIDS-defining events [crude incidence 18.6/1000 PYFU, 95% confidence interval (CI) 17.5-19.6] and 735 AIDS-defining events (crude incidence 11.7/1000 PYFU, 95% CI 10.8-12.5). Patients with thrombocytopenia (platelet count ≤100 × 10/l) had a slightly increased incidence of AIDS-defining events [adjusted incidence rate ratio (aIRR) 1.42, 95% CI 1.07-1.86], when compared to those with platelet counts 101-200 × 10/l, whereas the incidence of non-AIDS-defining events was more than two-fold higher (aIRR 2.66, 95% CI 2.17-3.26). Among non-AIDS-defining events, the adjusted incidence of cancer (aIRR 2.20, 95% CI 1.61-3.01), but not cardiovascular disease (aIRR 0.66, 95% CI 0.32-1.34), was significantly higher in patients with thrombocytopenia. The association between thrombocytopenia and cancer remained unaltered in sensitivity analyses requiring repeated platelet counts to confirm thrombocytopenia and lagging platelets by 1 year prior to clinical events. Conclusion: Patients with thrombocytopenia had increased incidence of AIDS-defining and non-AIDS-defining events, but the association with the latter, in particular cancer, was stronger. Future studies should investigate whether the pathophysiological processes underlying thrombocytopenia are associated with the development of cancer during treated HIV disease.pt_PT
dc.description.sponsorshipResearch support: Primary support for EuroSIDA is provided by the European Commission BIOMED 1 (CT94-1637), BIOMED 2 (CT97-2713), the 5th Framework (QLK2–2000-00773), the 6th Framework (LSHP-CT-2006-018632) and the 7th Framework (FP7/2007-2013, EuroCoord no. 260694) programmes. Current support also includes unrestricted grants from Bristol Myers Squibb, Janssen R&D, Merck and Co. Inc., Pfizer Inc. and GlaxoSmithKline LLC. The participation of centres from Switzerland was supported by The Swiss National Science Foundation (Grant 108787).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAIDS. 2014 Nov 13;28(17):2565-2571pt_PT
dc.identifier.doi10.1097/QAD.0000000000000433pt_PT
dc.identifier.eissn1473-5571
dc.identifier.issn0269-9370
dc.identifier.urihttp://hdl.handle.net/10451/51317
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Health, Inc.pt_PT
dc.relationCT94-1637pt_PT
dc.relationCT97-2713pt_PT
dc.relationQLK2–2000-00773pt_PT
dc.relationLSHP-CT-2006-018632pt_PT
dc.relationEuropean Network of HIV/AIDS Cohort Studies to Coordinate at European and International Level Clinical Research on HIV/AIDS
dc.relation.publisherversionhttps://journals.lww.com/aidsonline/pages/default.aspxpt_PT
dc.subjectBlood coagulationpt_PT
dc.subjectCancerpt_PT
dc.subjectCardiovascular diseasept_PT
dc.subjectHIVpt_PT
dc.subjectInflammationpt_PT
dc.subjectPlateletspt_PT
dc.subjectThrombocytopeniapt_PT
dc.titleThrombocytopenia is associated with an increased risk of cancer during treated HIV diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Network of HIV/AIDS Cohort Studies to Coordinate at European and International Level Clinical Research on HIV/AIDS
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/260694/EU
oaire.citation.endPage2571pt_PT
oaire.citation.issue17pt_PT
oaire.citation.startPage2565pt_PT
oaire.citation.titleAIDSpt_PT
oaire.citation.volume28pt_PT
oaire.fundingStreamFP7
person.familyNameAntunes
person.givenNameFrancisco
person.identifier.orcid0000-0001-7932-1154
person.identifier.scopus-author-id7006648941
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa28493a5-9101-4173-8863-74ee946d6ced
relation.isAuthorOfPublication.latestForDiscoverya28493a5-9101-4173-8863-74ee946d6ced
relation.isProjectOfPublicationc924f765-ee5a-4153-8e9f-e8dfbd61eb62
relation.isProjectOfPublication.latestForDiscoveryc924f765-ee5a-4153-8e9f-e8dfbd61eb62

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Thrombocytopenia_HIV.pdf
Size:
193.54 KB
Format:
Adobe Portable Document Format
Download

Collections

FM-ISAMB-Artigos em Revistas Internacionais