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SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10

2021Artigo científico Acesso aberto
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dc.contributor.authorGomes, André
dc.contributor.authorFarias, Guilherme B.
dc.contributor.authorDias Silva, Manuel
dc.contributor.authorLaia, Joel
dc.contributor.authorTrombetta, Amelia Chiara
dc.contributor.authorGodinho-Santos, Ana
dc.contributor.authorRosmaninho, Pedro
dc.contributor.authorSantos, Diana F.
dc.contributor.authorConceição, Carolina M.
dc.contributor.authorCosta Reis, Renato
dc.contributor.authorAdao-Serrano, Maria
dc.contributor.authorMota, Catarina
dc.contributor.authorAlmeida, Afonso
dc.contributor.authorSousa, Ana E.
dc.contributor.authorFernandes, Susana M.
dc.date.accessioned2023-05-26T14:15:51Z
dc.date.available2023-05-26T14:15:51Z
dc.date.issued2021
dc.description© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.pt_PT
dc.description.abstractAccelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of circulating ILCs at hospital admission, in agreement with overall lymphocyte depletion. However, ILCs recovered in direct correlation with lung function improvement as measured by oxygenation index and in negative association with inflammatory and lung/endothelial damage markers like RAGE. While both ILC1 and ILC2 expanded, ILC2 showed the most striking phenotype changes, with CCR10 upregulation in strong correlation with these parameters. Overall, CCR10+ ILC2 emerge as relevant contributors to SARS-CoV-2 pneumonia recovery.pt_PT
dc.description.sponsorshipThis work was funded by the following grants from Fundação para a Ciência e a Tecnologia (FCT), Portugal, through “APOIO ESPECIAL RESEARCH4COVID-19,” project numbers 125 to SMF and 803 to ACT. AMCG and GBF received fellowships funded by FCT (DOCTORATES4COVID-19, 2020.10202.BD) and JANSSEN- CILAG FARMACÊUTICA, respectively.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Immunol. 2021 Dec;51(12):3194-3201pt_PT
dc.identifier.doi10.1002/eji.202149311pt_PT
dc.identifier.eissn1521-4141
dc.identifier.issn0014-2980
dc.identifier.urihttp://hdl.handle.net/10451/57633
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationDOCTORATES4COVID-19, 2020.10202.BDpt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/15214141pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCCR10pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectInnate lymphoid cellspt_PT
dc.subjectLung recoverypt_PT
dc.subjectSARS-CoV2pt_PT
dc.titleSARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3201pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage3194pt_PT
oaire.citation.titleEuropean Journal of Immunologypt_PT
oaire.citation.volume51pt_PT
person.familyNameGomes
person.familyNameBorlido Farias
person.familyNameLaia
person.familyNameTrombetta
person.familyNameGodinho-Santos
person.familyNameRosmaninho
person.familyNameFeliciano dos Santos
person.familyNameM Conceição
person.familyNameCosta Reis
person.familyNameAdao-Serrano
person.familyNameMota da Silva
person.familyNameAlmeida
person.familyNameSousa
person.familyNameFernandes
person.givenNameAndré
person.givenNameGuilherme
person.givenNameJoel
person.givenNameAmelia Chiara
person.givenNameAna
person.givenNamePedro
person.givenNameDiana Isabel
person.givenNameCarolina
person.givenNameRenato
person.givenNameMaria
person.givenNameMaria Catarina
person.givenNameAfonso
person.givenNameAna E.
person.givenNameSusana
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person.identifier.ridL-2642-2014
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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