Ruminant fat intake improves gut microbiota, serum inflammatory parameter and fatty acid profile in tissues of Wistar rats

Medeiros, Larissa de Brito; Alves, Susana Paula; Bessa, R.J.B.; Soares, Juliana Késsia Barbosa; Costa, Camila Neves Meireles; Aquino, Jailane de Souza; Guerra, Gerlane Coelho Bernardo; Araújo, Daline Fernandes de Souza; Toscano, LydianeTavares; Silva, Alexandre Sérgio; Alves, Adriano Francisco; Lemos, Mateus Lacerda Pereira; Araujo, Wydemberg José de; Medeiros, Ariosvaldo Nunes de; Oliveira, Celso José Bruno de; Queiroga, Rita de Cassia Ramos do Egypto

http://hdl.handle.net/10400.5/22465

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Autores

Medeiros, Larissa de Brito

Alves, Susana Paula

Bessa, R.J.B.

Soares, Juliana Késsia Barbosa

Costa, Camila Neves Meireles

Aquino, Jailane de Souza

Guerra, Gerlane Coelho Bernardo

Araújo, Daline Fernandes de Souza

Toscano, LydianeTavares

Silva, Alexandre Sérgio

Resumo(s)

This study tested the hypothesis that naturally and industrially produced trans-fatty acids can exert distinct efects on metabolic parameters and on gut microbiota of rats. Wistar rats were randomized into three groups according to the diet: CONT-control, with 5% soybean oil and normal amount of fat; HVF-20% of hydrogenated vegetable fat (industrial); and RUM-20% of ruminant fat (natural). After 53 days of treatment, serum biochemical markers, fatty acid composition of liver, heart and adipose tissue, histology and hepatic oxidative parameters, as well as gut microbiota composition were evaluated. HVF diet intake reduced triglycerides (≈ 39.39%) and VLDL levels (≈ 39.49%). Transfatty acids levels in all tissue were higher in HVF group. However, RUM diet intake elevated amounts of anti-infammatory cytokine IL-10 (≈ 14.7%) compared to CONT, but not to HVF. Furthermore, RUM intake led to higher concentrations of stearic acid and conjugated linoleic acid in all tissue; this particular diet was associated with a hepatoprotective efect. The microbial gut communities were signifcantly diferent among the groups. Our results show that ruminant fat reversed the hepatic steatosis normally caused by high fat diets, which may be related to the remodelling of the gut microbiota and its anti-infammatory potential.

Descrição

Research Areas: Science & Technology - Other Topics

Palavras-chave

Diets Consunption Nutrition Health Trans-11 Obesity Food Cholesterol Metabolism Modulation

URI

http://hdl.handle.net/10400.5/22465

Citação

Medeiros LD, Alves SPA, Bessa RJB, Soares JKB, Costa CNM, Aquino JD, Guerra GCB, Araujo DFD, Toscano LT, Silva AS, et al. 2021. Ruminant fat intake improves gut microbiota, serum inflammatory parameter and fatty acid profile in tissues of Wistar rats. Scientifc Reports 11:18963. doi:10.1038/s41598-021-98248-6

Editora

NATURE RESEARCH

DOI

https://doi.org/10.1038/s41598-021-98248-6

Coleções

CIISA - Artigos em revistas internacionais

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