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Hepatic histology in obese patients undergoing bariatric surgery

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dc.contributor.authorMachado, Mariana
dc.contributor.authorMarques-Vidal, Pedro
dc.contributor.authorCortez-Pinto, Helena
dc.date.accessioned2021-05-13T11:03:33Z
dc.date.available2021-05-13T11:03:33Z
dc.date.issued2006
dc.description© 2006 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.pt_PT
dc.description.abstractBackground/aims: Obesity is one of the most important clinical associations with non-alcoholic steatohepatitis (NASH). Our aim was to assess the prevalence of non-alcoholic fatty liver disease (NAFLD)/NASH in morbidly obese patients and the risk factors to more aggressive liver disease in this population. Methods: Review of available studies on prevalence of NAFLD/NASH in severely obese patients submitted to bariatric surgery. Results: Twelve observational and transversal studies were included, with consecutive recruitment, and prospective evaluation of data, summing 1620 patients with severe obesity. Prevalence of steatosis and NASH was 91% (range: 85-98%) and 37% (24-98%), respectively, with unexpected cirrhosis in 1.7% (1-7%). NASH was not related with age or body mass index, but there was an association between male sex and NASH/hepatic fibrosis. Diabetes mellitus and insulin resistance were the conditions most frequently associated with NASH, and hypertension with advanced hepatic fibrosis. Conclusions: There is a very high prevalence of NAFLD in asymptomatic morbidly obese patients, more than one-third presenting histological criteria for NASH. This review underscores the large variations in prevalence of NASH between studies, calling for the need for a better agreement in the use of the histological criteria.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Hepatol. 2006 Oct;45(4):600-606pt_PT
dc.identifier.doi10.1016/j.jhep.2006.06.013pt_PT
dc.identifier.eissn1600-0641
dc.identifier.issn0168-8278
dc.identifier.urihttp://hdl.handle.net/10451/47827
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.journal-of-hepatology.eu/pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/journal-of-hepatologypt_PT
dc.subjectNon-alcoholic fatty liver diseasept_PT
dc.subjectNon-alcoholic steatohepatitispt_PT
dc.subjectMorbid obesitypt_PT
dc.subjectBariatric surgerypt_PT
dc.titleHepatic histology in obese patients undergoing bariatric surgerypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage606pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage600pt_PT
oaire.citation.titleJournal of Hepatologypt_PT
oaire.citation.volume45pt_PT
person.familyNameMarques-Vidal
person.familyNameCortez-Pinto
person.givenNamePedro
person.givenNameHelena
person.identifier.ciencia-idA01C-0511-C986
person.identifier.orcid0000-0002-4548-8500
person.identifier.orcid0000-0002-8537-8744
person.identifier.ridC-9449-2009
person.identifier.scopus-author-id55651163200
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd49496b1-af7a-430c-b616-0e52f9173e7c
relation.isAuthorOfPublication91fdb4b3-d491-4e67-94ff-dcf5013fa1a7
relation.isAuthorOfPublication.latestForDiscoveryd49496b1-af7a-430c-b616-0e52f9173e7c

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