Repository logo
 
Publication

Selenium and Redox Enzyme Activity in Pregnant Women Exposed to Methylmercury

2022-11-19Journal article Open access
Simple item page
dc.contributor.authorBranco, Vasco
dc.contributor.authorCarvalho, Luís
dc.contributor.authorBarboza, Cássia
dc.contributor.authorMendes, Maria Eduarda
dc.contributor.authorCavaco, Afonso
dc.contributor.authorCarvalho, Cristina
dc.date.accessioned2023-08-16T17:43:45Z
dc.date.available2023-08-16T17:43:45Z
dc.date.issued2022-11-19
dc.date.updated2022-11-22T12:11:06Z
dc.description.abstractSelenium (Se) is a micronutrient with essential physiological functions achieved through the production of selenoproteins. Adequate Se intake has health benefits and reduces mercury (Hg) toxicity, which is important due to its neurotoxicity. This study determined the Se status and redox enzyme, including selenoproteins’, activity in pregnant women highly exposed to Hg (between 1 to 54 µg Hg/L blood) via fish consumption. A cross-sectional study enrolling 513 women between the first and third trimester of pregnancy from Madeira, Portugal was conducted, encompassing collection of blood and plasma samples. Samples were analyzed for total Se and Hg levels in whole blood and plasma, and plasma activity of redox-active proteins, such as glutathione peroxidase (GPx), thioredoxin reductase (TrxR) and thioredoxin (Trx). Enzyme activities were related to Se and Hg levels in blood. Se levels in whole blood (65.0 ± 13.1 µg/L) indicated this population had a sub-optimal Se status, which translated to low plasma GPx activity (69.7 ± 28.4 U/L). The activity of TrxR (12.3 ± 5.60 ng/mL) was not affected by the low Se levels. On the other hand, the decrease in Trx activity with an increase in Hg might be a good indicator to prevent fetal susceptibility.pt_PT
dc.description.sponsorshipThis research was funded by the MERTOX-TRX project (PTDC/QUI- BIQ/117281/2010) and was partially financed by iMed, ULisboa’s strategic project UID/DTP/04138/2019. Vasco Branco is financed by national funds via FCT through Norma Transitória—DL57/2016/CP1376/CT002. The funding agency FCT was not involved in any phase of the work, including the treatment of results and the decision to submit them for publication.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBranco V, Carvalho L, Barboza C, Mendes E, Cavaco A, Carvalho C. Selenium and Redox Enzyme Activity in Pregnant Women Exposed to Methylmercury. Antioxidants [Internet]. 2022 Nov 19;11(11):2291. Available from: http://dx.doi.org/10.3390/antiox11112291pt_PT
dc.identifier.doi10.3390/antiox11112291pt_PT
dc.identifier.slugcv-prod-3083224
dc.identifier.urihttp://hdl.handle.net/10451/58901
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationResearch Institute for Medicines
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/11/11/2291pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSeleniumpt_PT
dc.subjectSelenoproteinspt_PT
dc.subjectPregnant womenpt_PT
dc.subjectThioredoxin reductasept_PT
dc.subjectGlutathione peroxidasept_PT
dc.subjectThioredoxinpt_PT
dc.subjectMercurypt_PT
dc.subjectRedox systemspt_PT
dc.titleSelenium and Redox Enzyme Activity in Pregnant Women Exposed to Methylmercurypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-BIQ%2F117281%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04138%2F2019/PT
oaire.citation.issue11pt_PT
oaire.citation.startPage2291pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameVeloso Neves Branco
person.familyNameMendes
person.familyNameCavaco
person.familyNameCarvalho
person.givenNameVasco Rui
person.givenNameMaria Eduarda
person.givenNameAfonso
person.givenNameCristina
person.identifierC-1144-2014
person.identifier147768
person.identifier.ciencia-id671C-816B-F077
person.identifier.ciencia-id3617-10D1-D66E
person.identifier.ciencia-idA01F-2A0F-E23A
person.identifier.ciencia-id5E17-EB04-EC9F
person.identifier.orcid0000-0002-0466-4934
person.identifier.orcid0000-0002-7926-8821
person.identifier.orcid0000-0001-8466-0484
person.identifier.orcid0000-0002-1097-7910
person.identifier.ridE-1398-2015
person.identifier.ridG-9298-2012
person.identifier.ridE-3379-2014
person.identifier.scopus-author-id8271087300
person.identifier.scopus-author-id7103403420
person.identifier.scopus-author-id55927486200
person.identifier.scopus-author-id35553159800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid671C-816B-F077 | Vasco Rui Veloso Neves Branco
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication06d8e0eb-35e5-4d30-90d8-5af2fdab414b
relation.isAuthorOfPublication3844460c-132b-41ca-a7ee-2d604c06fa4f
relation.isAuthorOfPublication3dd8fd20-b86a-4561-aa70-27503c229678
relation.isAuthorOfPublication1f53dbde-16e2-4faa-8c6e-b4f017e709b1
relation.isAuthorOfPublication.latestForDiscovery06d8e0eb-35e5-4d30-90d8-5af2fdab414b
relation.isProjectOfPublicationc4d72b72-6604-4303-a54a-c34acda839b8
relation.isProjectOfPublicationf7ed2a0a-c67e-4c12-ad63-b550724e24bf
relation.isProjectOfPublication.latestForDiscoveryf7ed2a0a-c67e-4c12-ad63-b550724e24bf

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Branco_et_al_2022_Antioxidants.pdf
Size:
2.57 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FF - CiênciaVitae - Faculdade de Farmácia