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Epicardial adipose tissue volume assessed by cardiac CT as a predictor of atrial fibrillation recurrence following catheter ablation

2024Journal article Open access
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dc.contributor.authorTeixeira, Bárbara Lacerda
dc.contributor.authorCunha, Pedro
dc.contributor.authorJacinto, Ana Sofia
dc.contributor.authorPortugal, Guilherme
dc.contributor.authorLaranjo, Sergio
dc.contributor.authorValente, Bruno
dc.contributor.authorLousinha, Ana
dc.contributor.authorCruz, Madalena Coutinho
dc.contributor.authorDelgado, Ana Sofia
dc.contributor.authorBrás, Manuel
dc.contributor.authorPaulo, Margarida
dc.contributor.authorGuerra, Cátia
dc.contributor.authorRamos, Ruben
dc.contributor.authorFontes, Iládia
dc.contributor.authorFerreira, Rui Cruz
dc.contributor.authorOliveira, Mario
dc.date.accessioned2024-05-29T15:13:05Z
dc.date.available2024-05-29T15:13:05Z
dc.date.issued2024
dc.description© 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)pt_PT
dc.description.abstractIntroduction: In patients with atrial fibrillation (AF), up to one third have recurrence after a first catheter ablation (CA). Epicardial adipose tissue (EAT) has been considered to be closely related to AF, with a potential role in its recurrence. We aimed to evaluate the association between the volume of EAT measured by cardiac computed tomography (CT) and AF recurrence after CA. Methods: Consecutive AF patients underwent a standardized cardiac CT protocol for quantification of EAT, thoracic adipose volume (TAV) and left atrium (LA) volume before CA. An appropriate cut-off of EAT was determined and risk recurrence was estimated. Results: 305 patients (63.6 % male, mean age 57.5 years, 28.2 % persistent AF) were followed for 24 months; 23 % had AF recurrence at 2-year mark, which was associated with higher EAT (p = 0.037) and LAV (p < 0.001). Persistent AF was associated with higher EAT volumes (p = 0.010), TAV (p = 0.003) and LA volumes (p < 0.001). EAT was predictive of AF recurrence (p = 0.044). After determining a cut-off of 92 cm3, survival analysis revealed that EAT volumes > 92 cm3 showed higher recurrence rates at earlier time points after the index ablation procedure (p = 0.006), with a HR of 1.95 (p = 0.008) of AF recurrence at 2-year. After multivariate adjustment, EAT > 92 cm3 remained predictive of AF recurrence (p = 0.028). Conclusion: The volume of EAT measured by cardiac CT can predict recurrence of AF after ablation, with a volume above 92 cm3 yielding almost twice the risk of arrhythmia recurrence in the first two years following CA. Higher EAT and TAV are also associated with persistent AF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Imaging. 2024 Jun:110:110170pt_PT
dc.identifier.doi10.1016/j.clinimag.2024.110170pt_PT
dc.identifier.eissn1873-4499
dc.identifier.issn0899-7071
dc.identifier.urihttp://hdl.handle.net/10451/64925
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/clinical-imagingpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAtrial fibrillationpt_PT
dc.subjectCardiac CTpt_PT
dc.subjectCardiovascular imagingpt_PT
dc.subjectCatheter ablationpt_PT
dc.subjectEpicardial fatpt_PT
dc.titleEpicardial adipose tissue volume assessed by cardiac CT as a predictor of atrial fibrillation recurrence following catheter ablationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleClinical Imagingpt_PT
oaire.citation.volume110pt_PT
person.familyNameSilva Cunha
person.familyNameLaranjo
person.familyNameRamos
person.familyNameCruz Ferreira
person.familyNameMartins Oliveira
person.givenNamePedro Miguel
person.givenNameSergio
person.givenNameRuben
person.givenNameRui Manuel
person.givenNameMario Joao
person.identifier36332
person.identifier.ciencia-id4716-747F-D64E
person.identifier.ciencia-id351B-92E1-0C50
person.identifier.ciencia-id361A-53B6-9526
person.identifier.ciencia-id2312-2190-19B2
person.identifier.orcid0000-0001-9465-634X
person.identifier.orcid0000-0003-2169-4024
person.identifier.orcid0000-0003-0736-3878
person.identifier.orcid0000-0002-9747-5293
person.identifier.orcid0000-0002-8371-8354
person.identifier.ridG-2909-2011
person.identifier.scopus-author-id24391148400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication77292f94-3ad4-4657-bba0-c54ab9dd641a
relation.isAuthorOfPublication902d64d7-c6bf-4b05-8f49-3b52dd0aa452
relation.isAuthorOfPublication11848a40-bf53-4d5f-8cc6-696f03754600
relation.isAuthorOfPublication540a4d03-1809-4baf-92e1-a3a72d4da2f7
relation.isAuthorOfPublication81e0b444-8832-47a8-a911-2f89eb33545d
relation.isAuthorOfPublication.latestForDiscovery902d64d7-c6bf-4b05-8f49-3b52dd0aa452

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