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Correlation between hyperglycemia and glycated albumin with retinopathy of prematurity

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dc.contributor.authorAlmeida, Ana C.
dc.contributor.authorSilva, Gabriela A.
dc.contributor.authorSantini, Gabriele
dc.contributor.authorBrízido, Margarida
dc.contributor.authorCorreia, Miguel
dc.contributor.authorCoelho, Constança
dc.contributor.authorBorrego, Luís Miguel
dc.date.accessioned2021-12-09T15:11:50Z
dc.date.available2021-12-09T15:11:50Z
dc.date.issued2021
dc.description© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractTo determine the association between hyperglycemia, glycated albumin (GlyA) and retinopathy of prematurity (ROP). Prospective study of all infants under ROP screening from March 2017 to July 2019. All demographic, clinical and laboratory data were collected. Glucose was measured at birth and every 8 h for the first week and serum GlyA was evaluated at birth, 1st, 2nd and 4th weeks after birth. Reference range for GlyA was obtained. Univariate logistic regression was used to examine risk factors for ROP followed by multivariate regression. A total of 152 infants were included in the study. Median gestational age was 30 weeks and median birth weight 1240 g. Thirty-three infants (21.7%) had ROP. Hyperglycemia was present in 24 (72.7%) infants diagnosed with any ROP versus 6 (0.05%) in those without ROP. Median GlyA at birth, 1st, 2nd and 4th and respective reference ranges were 8.50% (6.00-12.65), 8.20% (5.32-11.67), 8.00% (5.32-10.00) and 7.90% (5.30-9.00) respectively. After multivariate logistic regression, hyperglycemia but not GlyA, remained a significant risk factor for ROP overpowering the other recognized risk factors (Exp (B) 28.062, 95% CI for Exp(B) 7.881-99.924 p < 0.001). In our cohort, hyperglycemia but not GlyA, remained a significant risk factor for ROP overpowering the other recognized risk factors.pt_PT
dc.description.sponsorshipThe present publication was funded by Fundação Ciência e Tecnologia, IP national support through CHRC (UIDP/04923/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep. 2021 Nov 16;11(1):22321pt_PT
dc.identifier.doi10.1038/s41598-021-01861-8pt_PT
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10451/50311
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
dc.relation.publisherversionhttps://www.nature.com/srep/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleCorrelation between hyperglycemia and glycated albumin with retinopathy of prematuritypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04923%2F2020/PT
oaire.citation.issue1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCoelho
person.givenNameConstança
person.identifier.ciencia-id7515-8385-064B
person.identifier.orcid0000-0002-5331-2257
person.identifier.scopus-author-id7005608345
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6b90db77-8f9c-48a9-a91e-6410d4b862e6
relation.isAuthorOfPublication.latestForDiscovery6b90db77-8f9c-48a9-a91e-6410d4b862e6
relation.isProjectOfPublication919196a0-040d-4895-a2fd-17799fff82f9
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